PMID: 9189637Jan 1, 1997Paper

The antibiotic selective process: concentration-specific amplification of low-level resistant populations

Ciba Foundation Symposium
F BaqueroJ Blázquez

Abstract

The biochemistry and genetics of antibiotic resistance are far better known than the equally important events underlying the selection of resistant populations. The hidden selection of low-level resistant variants may be a key process in the emergence of high-level antibiotic resistance. Different low-level resistant bacterial subpopulations may be specifically selected by different low antibiotic concentrations. The space in the environment (human body) where a given selective concentration exists represents the selective compartment. For pharmacokinetic reasons, low antibiotic concentrations occur in a larger selective compartment and persist longer than high antibiotic concentrations. The specific selection of low-level variants by low concentrations of antibiotic can be reproduced in experimental in vitro models using mixtures of susceptible and low-level resistant populations. We demonstrated this in Escherichia coli strains harbouring TEM-1, TEM-12 and TEM-10 beta-lactamases challenged by cefotaxime, and also Streptococcus pneumoniae strains with various levels of penicillin resistance challenged by amoxicillin or cefotaxime. In both cases, four hours of antibiotic challenge produced selective peaks of low-level resistant...Continue Reading

Citations

Apr 30, 2005·The Journal of Antimicrobial Chemotherapy·Linda L MarcussonDiarmaid Hughes
Nov 25, 2004·Antimicrobial Agents and Chemotherapy·Jeffrey J CampionMartin E Evans
May 27, 2005·Antimicrobial Agents and Chemotherapy·Jeffrey J CampionMartin E Evans
Dec 24, 2004·Antimicrobial Agents and Chemotherapy·Jeffrey J CampionMartin E Evans
Apr 6, 2021·Frontiers in Microbiology·Fernando BaqueroJose L Martinez
Apr 30, 2021·MSphere·Christopher FröhlichHanna-Kirsti S Leiros

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