The antibodies against Bordetella pertussis in sera of patients with Parkinson's disease and other non-neurological diseases

Acta Neurologica Scandinavica
U FiszerW Palasik

Abstract

It has been reported that the prevalance of parkinsonism might be associated with exposure to whooping cough. Examination of levels of antibodies against Bordetella pertussis in serum using enzyme-linked immunosorbent assay (ELISA) tests [presence of IgG antibodies against filamentous hemagglutinin and pertussis toxin (PT)] were performed in 81 persons (including 45 patients with controls) (age-matched groups). Positive results were found in patients with Parkinson's disease (PD), patients with other non-inflammatory diseases, and controls (about 40-45% in each group). A detailed examination of separate responses (IgG and IgA antibodies against PT, and a whole cell immune response) and of the serum level of immunoglobulins IgG, IgA and IgM was also performed. Our results demonstrate numerous cases of whooping cough serum antibodies among the adult population (also among PD patients). The results of our research, i.e. a common occurrence of Bordetella pertussis infection do not provide evidence of relationship between PD and the above-mentioned infection.

References

May 1, 1967·Neurology·M M Hoehn, M D Yahr
Jan 1, 1994·Journal of the Neurological Sciences·U FiszerH Link
Mar 1, 1996·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J E Hoppe
Dec 1, 1996·International Journal of Epidemiology·J de Pedro-CuestaI J Petersen
Jan 29, 1999·Archives of Neurology·D J GelbS Gilman
Feb 24, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G K Robbins
Jan 23, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Peter TeismannSerge Przedborski

❮ Previous
Next ❯

Citations

Feb 17, 2017·Parkinsonism & Related Disorders·Arun Parashar, Malairaman Udayabanu
Nov 7, 2015·Paediatric Drugs·Abdulbaset M SalimPaul E Kilgore
Jun 3, 2011·European Journal of Epidemiology·Karin WirdefeldtJack Mandel
Jul 6, 2019·Frontiers in Neurology·Nattakarn LimphaiboolWojciech Kozubski

❮ Previous
Next ❯

Related Concepts

Related Papers

Enfermedades infecciosas y microbiología clínica
Sandra ManzanaresJoan A Caylà
Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)
A Ferrer MarcellesI Planells Romeu
© 2022 Meta ULC. All rights reserved