PMID: 489965Oct 1, 1979Paper

The antibody response in Legionnaires' disease

The Journal of Hygiene
J NagingtonA D Macrae

Abstract

From 22 patients with Legionnaires' disease, 86 sera were examined for specific serotype 1 IgM and IgG antibodies by the indirect immunofluorescence technique. No antibody was detectable until 8 days or more from the onset of symptoms. When produced the amount was widely variable and remained detectable for periods from less than 34 days to more than 1 year. Intially IgM antibody predominated, ten patients produced only IgM in the first 21 days, six produced only IgM in the first 28 days and three did not produce IgG at any time. One patient, and possibly a second, produced only IgG antibody. Since IgM antibody was still present in one patient after a year it is important not to accept the presence of this as evidence of very recent infection. It is advisable that any type of serological test for L. pneumophila infection should detect the production of both IgM and IgG antibodies.

References

Nov 25, 1978·Lancet·J NagingtonT G Wreghitt
Dec 1, 1977·The New England Journal of Medicine·D W FraserP S Brachman
Jan 1, 1979·British Journal of Diseases of the Chest·P JenkinsJ M Rowley

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Citations

Jul 5, 2002·Clinical Microbiology Reviews·Barry S FieldsRichard E Besser
Apr 1, 1983·Journal of Clinical Pathology·M Holliday
Jun 1, 1985·British Journal of Industrial Medicine·D H DaviesC D Ribeiro
Dec 16, 2004·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J W Den Boer, E P F Yzerman
Feb 1, 1987·European Journal of Clinical Microbiology·P H Edelstein
Jan 1, 1981·Scandinavian Journal of Infectious Diseases·D A Hartigan
Jun 15, 2011·Journal of Microbiological Methods·Pernille L ElverdalSøren A Uldum
Sep 8, 1979·Lancet·J NagingtonD J Smith
Oct 1, 1983·International Journal of Dermatology·E PanconesiM Sarti
Jan 1, 1983·Scandinavian Journal of Infectious Diseases·K NordströmF Clemens
Sep 18, 1989·The Medical Journal of Australia·T W Steele
Dec 1, 1982·Journal of Clinical Microbiology·S E ZimmermanR B Kohler
Jan 1, 1988·Clinical Microbiology Reviews·W C Winn
Oct 1, 1986·American Journal of Infection Control·T J MarrieD Haase

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