PMID: 11934565Apr 6, 2002Paper

The antibody response to bacteriophage is linked to the lymphopenia gene in congenic BioBreeding rats

FEMS Immunology and Medical Microbiology
Leila ClarkH D Ochs

Abstract

Congenic BioBreeding (BB) rats, homozygous for the autosomal lymphopenia (Lyp) gene (Lyp/Lyp), heterozygous (Lyp/+), or wild-type (+/+), were immunized with the T cell-dependent bacteriophage PhiX174 to determine effects of Lyp on primary and secondary antibody responses. The primary PhiX174 antibody response did not differ between the three different genotypes. In contrast, the secondary immune response, expressed as the peak neutralizing titer, was markedly reduced in Lyp/Lyp (9.9+/-3.2; mean value+/-S.E.M. for seven rats) compared to both Lyp/+ (51+/-12; n=13; P=0.006) and +/+ (100+/-20; n=7; P=0.004) BB rats. We suggest that the secondary antibody response to the T cell-dependent neoantigen PhiX174 is linked in a recessive manner to genetic factor(s) in the Lyp gene region.

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Citations

May 31, 2003·Nature Reviews. Drug Discovery·Carl R MerrilSankar L Adhya
Feb 16, 2012·Bacteriophage·Stephen T AbedonElizabeth Martin Kutter
Nov 2, 2019·Microbiology and Molecular Biology Reviews : MMBR·Krystyna Dąbrowska, Stephen T Abedon
Jan 4, 2021·Current Opinion in Biotechnology·Katarzyna Gembara, Krystyna Dąbrowska

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