PMID: 6169338Dec 1, 1980Paper

The antibody response to myoglobin is independent of the immunized species. Analysis in terms of replacements in the antigenic sites and in environmental residues of the cross-reactions of fifteen myoglobins with sperm-whale myoglobin antisera raised in different species

The Biochemical Journal
S S TwiningM Z Atassi

Abstract

The recent determination of the entire antigenic structure of sperm-whale myoglobin with rabbit and goat antisera has permitted the examination of whether the antigenic structure recognized by antibodies depends on the species in which the antisera are raised. Also, by knowledge of the antigenic structure, the molecular factors that determine and influence antigenicity can be better understood in terms of the effects of amino acid substitutions occurring in the antigenic sites and in the environmental residues of the sites. In the present work, the myoglobins from finback whale, killer whale, horse, chimpanzee, sheep, goat, bovine, echidna, viscacha, rabbit, dog, cape fox, mouse and chicken were examined for their ability to cross-react with antisera to sperm-whale myoglobin. By immunoadsorbent titration studies with radioiodinated antibodies, each of these myoglobins was able to bind antibodies to sperm-whale myoglobin raised in goat, rabbit, chicken, cat, pig and outbred mouse. It was found that the extent of cross-reaction of a given myoglobin was not dependent on the species in which the antisera were raised. This indicated that the antibody response to sperm-whale myoglobin (i.e. its antigenic structure) is independent of ...Continue Reading

Citations

Oct 1, 1981·Journal of Immunogenetics·C R YoungM Z Atassi
Jan 1, 1983·Biopolymers·S J Leach
Feb 8, 1990·Nature·R J Petrella, M M Yokoyama
Jul 20, 2007·Clinical and Vaccine Immunology : CVI·John FerbasSteven J Swanson
Jul 24, 2002·Journal of Immunological Methods·Gordon Tribbick
Jun 1, 1984·Molecular Immunology·H M CooperS J Leach
Aug 16, 2006·Legal Medicine·Shinichiro TsuruyaIchiro Nakasono

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