The Anticancer Effect of Sanguinarine: A Review

Current Pharmaceutical Design
Chenxing FuHongbing Wang

Abstract

In vitro and in vivo studies have revealed that Sanguinarine has antioxidant, anti-inflammatory, proapoptotic, and growth inhibitory effects on tumor cells of a variety of cancers. Previous research showed that sanguinarine induced apoptosis (cell death) and/or antiproliferative while reducing tumor cell antiangiogenic and anti-invasive properties. This paper describes various sanguinarine anti-cancer mechanisms, including inhibition of erroneously-activated signal transduction pathways, apoptosis, and tumor cell proliferation inhibition.

Citations

May 15, 2020·Biological & Pharmaceutical Bulletin·Mingzhi LuoLinhong Deng
Oct 30, 2020·Antioxidants & Redox Signaling·Junmin ZhangJianguo Fang
Jul 9, 2021·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Guang-Han FanXiao Xu
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sharna-Kay Daley, Geoffrey A Cordell
Jul 30, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Beilei ZhangFu Wang
Aug 29, 2021·Phytochemistry·Toktam AkaberiMaryam Akaberi

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