The anticancer effects of actinoporin RTX-A from the sea anemone Heteractis crispa (=Radianthus macrodactylus).

Toxicon : Official Journal of the International Society on Toxinology
Sergey N FedorovValentin A Stonik

Abstract

Four isoforms of actinoporins were isolated in 2002-2004 from the tropical sea anemone Heteractis crispa (=Radianthus macrodactylus). Their potent hemolytic activities and effects on Ehrlich ascites carcinoma bearing mice were also studied. In this study, the individual actinoporin (RTX-A) demonstrated potential cancer-preventive activity at extremely low and non-cytotoxic concentrations. The substance suppressed the malignant transformation of mouse JB6 P(+) Cl41 cells stimulated by epidermal growth factor (EGF) in soft agar with the inhibition of number of the colonies C(50) (INCC(50))=0.034 nM. Actinoporin RTX-A also was shown to inhibit the phenotype expression of HeLa human cancer cells with an INCC(50)=0.03 nM. The cytotoxic effect of RTX-A against JB6 P(+) Cl41 cells and HeLa, THP-1, MDA-MB-231, and SNU-C4 human tumor cell lines was high (IC(50)=0.57, 2.26, 1.11, 30.0 and 4.66 nM), but significantly less than their capacity to suppress tumor cell colony formation or phenotype expression. RTX-A also induced apoptosis and inhibited basal AP-1, NF-kappaB, and p53-dependent transcriptional activity in JB6 Cl41 cells. These results confirmed that actinoporin RTX-A from H. crispa, at least partially, might exhibit cancer-preve...Continue Reading

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Citations

Mar 19, 2014·European Journal of Medicinal Chemistry·Dmitry N PelageevVictor Ph Anufriev
Aug 31, 2013·Cytotechnology·Mahnaz RamezanpourBarbara J S Sanderson
Jun 23, 2015·Toxins·Mahdokht JouiaeiBryan G Fry
Jun 25, 2013·Expert Opinion on Investigational Drugs·Su-Juan WangLu-Ping Qin
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May 31, 2011·Biochimica Et Biophysica Acta·Lucía García-OrtegaJosé G Gavilanes
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Jul 19, 2015·Toxicon : Official Journal of the International Society on Toxinology·A ValleI F Pazos
Oct 6, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wei Yuen Yap, Jung Shan Hwang
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Apr 4, 2013·Bioorganicheskaia khimiia·S A KozlovE V Grishin
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Aug 28, 2020·Journal of Immunoassay & Immunochemistry·Sadra Samavarchi TehraniMortaza Taheri-Anganeh
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