PMID: 9532321Apr 9, 1998Paper

The anticholinergic agent, ipratropium bromide, is useful in the treatment of rhinorrhea associated with perennial allergic rhinitis

Allergy and Asthma Proceedings
H B KaiserC C Wood

Abstract

The effects of the new ipratropium bromide nasal spray on rhinorrhea associated with perennial allergic rhinitis were studied in 219 patients over eight weeks in a multicenter, randomized, double-blind trial. The purpose of the study was to determine whether the new spray reduces nasal hypersecretion in allergic patients without causing excessive dryness or other potential cholinergic side effects. The investigators compared two doses of the spray (42 or 84 mcg/nostril t.i.d.) to placebo. Two hundred and nineteen patients were admitted to the study; 176 completed it. Study design included one week of screening to confirm a diagnosis of perennial allergic rhinitis with clinically significant rhinorrhea, one week of single-blind treatment with a placebo consisting of the saline vehicle of the spray, an eight-week double-blind treatment-comparison period, and one week of follow-up without treatment. Both doses of ipratropium bromide nasal spray significantly reduced the hypersecretion associated with PAR, compared with placebo. The two doses of active drug were equally effective. Treatment differences were noticeable during the first week and remained relatively stable during the eight-week treatment period. There was no evidence ...Continue Reading

Citations

Jun 2, 2010·Clinical Reviews in Allergy & Immunology·Robert A Nathan
May 22, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Bradley F MarpleUNKNOWN American Academy of Otolaryngic Allergy Working Group on Allergic Rhinitis
Feb 11, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Kenneth T KimUNKNOWN Pediatric Atrovent Nasal Spray Study Group
Sep 10, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·H MilgromC C Wood
Nov 27, 2009·Postgraduate Medicine·Bradley F MarpleUNKNOWN American Academy of Otolaryngic Allergy Working Group on Chronic Rhinosinusitis
Jul 16, 2009·Drug Metabolism Reviews·Jean-Baptiste WateletBertrand Diquet
Jul 10, 2013·Revue des maladies respiratoires·R Harf
Dec 18, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G K ScaddingUNKNOWN British Society for Allergy and Clinical Immunology
Jan 1, 2009·The World Allergy Organization Journal·Robert Naclerio
Feb 14, 2018·International Forum of Allergy & Rhinology·Sarah K WiseMark Zacharek
Aug 13, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Robert J LeeNoam A Cohen
Jul 6, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Zihan JiangJuan Meng
Jul 1, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G K ScaddingA T Clark
May 3, 2019·Respiratory Medicine·Mario CazzolaMaria Gabriella Matera

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