The anticoagulant activity of lysosomal cationic proteins from polymorphonuclear leukocytes

The Journal of Clinical Investigation
H I SabaJ C Herion

Abstract

A cationic protein fraction from rabbit polymorphonuclear leukocyte lysosomes has been shown to exert a potent anticoagulant effect on human blood in vitro. The anticoagulant activity is detectable in the whole blood clotting time, the recalcification time of platelet-rich plasma, the prothrombin time, the partial thromboplastin time, and the thromboplastin generation test. The lysosomal cationic proteins do not inhibit any of the known specific procoagulants. They appear to inhibit clotting by blocking the formation of intrinsic thromboplastin possibly by interfering with the role of phospholipids in the reaction involving Factors V and X and calcium.

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Citations

Sep 1, 1970·Arthritis and Rheumatism
Dec 1, 1974·Die Naturwissenschaften·D J Giannitsis, St Pekker
May 1, 1986·Thrombosis Research·H I SabaG A Morelli
Aug 1, 1974·The Journal of Experimental Medicine·G J GleichK G Mann
Feb 1, 1970·The Journal of Clinical Investigation·R L NachmanB Ferris
Feb 1, 1972·The Journal of Clinical Investigation·J Niemetz
Mar 1, 1978·Thrombosis Research·H I SabaS R Saba
Mar 1, 1970·The American Journal of Medicine·J W Hampton
Oct 27, 1972·Annals of the New York Academy of Sciences·R L Nachman, B Weksler

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