The anticonvulsant action of propofol on epileptiform activity in rat hippocampal slices.

Anesthesia and Analgesia
Hideya OhmoriAkiyoshi Namiki

Abstract

We used extracellular electrophysiological recordings from the CA1 region in rat hippocampal slices to investigate the effects of propofol on the field excitatory postsynaptic potential (fEPSP), population spike, and epileptiform activity induced by a Mg(2+)-free condition. Propofol depressed the population spike, fEPSP, and epileptiform activity. Both aminophylline, a nonselective adenosine receptor antagonist, and 8-cyclopentyl-1,3-dipropylxanthine, an A(1) receptor antagonist, significantly reduced the effect of propofol on fEPSP amplitude. However, 3,7-dimethyl-1-propagylxanthine, an A(2) receptor antagonist, did not alter the effect of propofol on fEPSP amplitude. Picrotoxin, a specific chloride channel blocker, partly reduced the effect of propofol on epileptiform activity, but bicuculline, a competitive gamma-aminobutyric acid(A) receptor antagonist, failed to antagonize it. Aminophylline significantly reduced the action of propofol on the epileptiform activity. The anticonvulsant action of propofol was partly reduced by 8-cyclopentyl-1,3-dipropylxanthine, whereas 3,7-dimethyl-1-propagylxanthine failed to affect it. Adenosine depressed the amplitude of fEPSPs in a dose-dependent manner, and propofol enhanced this inhibit...Continue Reading

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Citations

Nov 29, 2012·The Journal of Clinical Investigation·Irene LeckerBeverley A Orser
Jan 15, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Daniel San-juanAndrew J Cole
Mar 14, 2008·Journal of Pharmacological and Toxicological Methods·Matthew J WinterThomas H Hutchinson
Aug 12, 2005·Journal of Neurophysiology·Xiangdong ChenDouglas A Bayliss
Sep 15, 2010·The Journal of Pharmacology and Experimental Therapeutics·Ashish DhirMichael A Rogawski
May 19, 2009·Anesthesia and Analgesia·Sascha MeyerGhiath Shamdeen
Apr 4, 2021·Journal of Clinical Medicine·Francesco AlessandriFederico Bilotta

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