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The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist

Proceedings of the National Academy of Sciences of the United States of America

Sep 1, 1986

E H WongL L Iversen

PMID: 3529096

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Abstract

The compound MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine maleate)] is a potent anticonvulsant that is active after oral administration and whose mechanism of action is unknown. We have detected high-affinity (Kd = 37.2 +/- 2.7 nM) binding sites for [3H]MK-8...read more

Mentioned in this Paper

Phencyclidine
Kainate
Medulla Oblongata
Enantiomer
Entire Corpus Striatum
MK-801
Neurotransmitters
Phencyclidine Hydrobromide
Entire Medulla Oblongata
Tissue Membrane
175
1
Paper Details
References
  • References16
  • Citations1168
12
  • References16
  • Citations1168
12345...

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The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist

Proceedings of the National Academy of Sciences of the United States of America

Sep 1, 1986

E H WongL L Iversen

PMID: 3529096

DOI:

Abstract

The compound MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine maleate)] is a potent anticonvulsant that is active after oral administration and whose mechanism of action is unknown. We have detected high-affinity (Kd = 37.2 +/- 2.7 nM) binding sites for [3H]MK-8...read more

Mentioned in this Paper

Phencyclidine
Kainate
Medulla Oblongata
Enantiomer
Entire Corpus Striatum
175
1

Related Papers

Paper Details
References
  • References16
  • Citations1168
12
  • References16
  • Citations1168
12345...

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