The antidepressant-like effect of chronic guanosine treatment is associated with increased hippocampal neuronal differentiation

The European Journal of Neuroscience
Luis E B BettioAna Lúcia S Rodrigues

Abstract

Guanosine is a purine nucleoside that occurs naturally in the central nervous system (CNS), exerting trophic effects. Given its neuroprotective properties, the potential of guanosine as an antidepressant has been recently examined. Within this context, the present study sought to investigate the effects of chronic treatment with guanosine on the tail suspension test (TST), open field test and on adult hippocampal neurogenesis. Swiss mice were administered guanosine for 21 days (5 mg/kg/day, p.o.) and subsequently submitted to the TST and open-field test. Following behavioral testing, animals were sacrificed and the brains were processed for immunohistochemical analyses of hippocampal cell proliferation and neuronal differentiation. Animals treated with guanosine showed a reduction in immobility time in the TST without alterations in locomotor activity, confirming the antidepressant-like effect of this compound. Quantitative microscopic analysis did not reveal significant alterations in the numbers of Ki-67- and proliferating cell nuclear antigen (PCNA)-positive cells in the hippocampal dentate gyrus (DG) of guanosine-treated mice. However, guanosine treatment resulted in a significant increase in the number of immature neurons,...Continue Reading

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Citations

Mar 24, 2016·Purinergic Signalling·Luis E B BettioAna Lúcia S Rodrigues
Jul 6, 2016·Frontiers in Pharmacology·Valentina Di LibertoNatale Belluardo
Oct 1, 2019·Anatomia, histologia, embryologia·Louise C Abbott, Fikru Nigussie
Jun 28, 2020·Molecular Neurobiology·Tetsade C B PiermartiriCarla Inês Tasca
Nov 20, 2016·Neural Regeneration Research·Luis E B BettioAna Lúcia S Rodrigues
May 23, 2020·Scientific Reports·Roberto Farina de AlmeidaDiogo O Souza
May 23, 2020·Chronic Stress·Anderson Camargo, Ana Lúcia S Rodrigues
Aug 15, 2018·Molecular Neurobiology·Fernando DobrachinskiFélix A A Soares
Nov 22, 2018·Frontiers in Cellular Neuroscience·Carla I TascaFrancisco Ciruela
May 14, 2020·Neurotoxicity Research·Gislaine OlescowiczAna Lúcia S Rodrigues
Dec 10, 2020·International Journal of Molecular Sciences·Monica FrinchiGiuseppa Mudò
Mar 14, 2021·Purinergic Signalling·Priscila B RosaAna Lúcia S Rodrigues
May 1, 2021·Frontiers in Pharmacology·Roberto F AlmeidaElaine Elisabetsky
Aug 24, 2021·Frontiers in Psychiatry·Roberto Farina AlmeidaDiogo O Souza

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