Abstract
Chaihu Shugan San (CSS), a traditional Chinese medicine formula, has been used to treat depression for hundreds of years. Recently, the antidepressant-like mechanism of CSS has been increasingly evaluated and demonstrated. However, there are few studies focused on the involvement of the neurotrophic system in mediating the antidepressant-like effects of CSS. Considering the high prevalence of perimenopausal depression around the world, the goal of the present study was to determine whether brain-derived neurotrophic factor (BDNF) signaling is required for the antidepressant-like effects of CSS in perimenopausal depressive-like rats. The results indicate that CSS reverses depressive-like behaviors and attenuates the downregulation of BDNF in the hippocampus of perimenopausal rats exposed to chronic unpredictable mild stress (CUMS). We found that the TrkB antagonist K252 not only blocks the effects of CSS on behavioral improvement but also abolishes the activation of CSS in BDNF-TrkB signaling. As a result, the downstream targets of BDNF signaling, such as the ERK and Akt pathways, are significantly inhibited by K252a. Furthermore, CSS increases hippocampal neurogenesis, while K252a fully prevents this action. In conclusion, the ...Continue Reading
References
Feb 25, 2003·Annual Review of Neuroscience·Rosalind A Segal
Jun 18, 2005·The Journal of Clinical Psychiatry·Melinda L MorganAndrew F Leuchter
Jul 22, 2009·Molecular Psychiatry·D TaliazA Zangen
Nov 13, 2010·International Journal of Women's Health·Barbara L Parry
May 15, 2012·Neuropharmacology·Neil M FournierRonald S Duman
Sep 10, 2013·PloS One·Shujiao ChenCandong Li
Jul 19, 2014·Psychopharmacology·Bin-Bin LiuLi-Tao Yi
Jul 30, 2014·Frontiers in Neuroscience·Christina M MerkleyJ Martin Wojtowicz
Aug 1, 2014·Journal of Psychiatry & Neuroscience : JPN·Li-Tao YiDi Geng
Dec 5, 2014·Gerontology·Désirée R M Seib, Ana Martin-Villalba
Jan 15, 2015·The American Journal of Psychiatry·Jennifer L GordonKatherine L Wisner
Sep 4, 2015·Indian Journal of Psychiatry·Pronob K Dalal, Manu Agarwal
Oct 31, 2015·Psychopharmacology·Wen-Xue LiuJian-Jun Yang
Jan 21, 2016·Archives of Medical Science : AMS·Siresha Bathina, Undurti N Das
May 22, 2016·The International Journal of Neuropsychopharmacology·Bo JiangLi-Juan Tong
Jul 8, 2016·Psychopharmacology·Rong-Hao MuLi-Tao Yi
Oct 25, 2016·Journal of Affective Disorders·M de KruifM L Molendijk
Feb 22, 2017·Maturitas·Tae-Hun KimTerje Alraek
Aug 2, 2017·Scientific Reports·Tingxu YanYing Jia
Sep 30, 2017·Neuroscience Letters·Xue-Qin ChenCan-Dong Li
Citations
Feb 6, 2019·Journal of Cellular Biochemistry·Tao ShenYunfeng Li
Oct 22, 2019·Journal of Separation Science·Heyun ZhuJingkai Gu
Feb 14, 2020·Metabolites·Meng YuZhong-Mei Zou
Jul 31, 2020·Neurological Research·Quan LuCongfeng Tang
Aug 23, 2018·Molecular Medicine Reports·Delong TianZhenzhen Tian
Jul 25, 2019·Chinese Medicine·Zhengrong ZhangGuoqi Zhu
Jul 11, 2020·Scientific Reports·Suhyeon KimKyungae Jo
Aug 1, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Dao-Zhou MuXi Huang
Apr 23, 2020·Animal Models and Experimental Medicine·Li-Wen HeYi Tan
Oct 18, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li-Hua CaoXiu-Min Li
Sep 22, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Le WangFeng Liu
Sep 3, 2020·Journal of Affective Disorders·Jin-Liang WangBo Jiang
Sep 30, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qiang ZengZhengzhi Wu
Feb 7, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ya-Hui XuJia-Xu Chen
Jan 22, 2021·Phytotherapy Research : PTR·Ning JiangXin-Min Liu
Mar 21, 2021·Journal of Dairy Science·Hsiao-Ling ChenChuan-Mu Chen
Mar 24, 2021·Journal of Ethnopharmacology·Jie ChengLi-Tao Yi
Jun 3, 2021·International Journal of Molecular Sciences·Bernice Lottering, Yi-Wen Lin
Jul 20, 2021·Behavioural Brain Research·Zhixia JiaLin Pei
Aug 14, 2021·Drug Design, Development and Therapy·Shan ZhangLi Li
Apr 26, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lan LiXi Huang
Dec 8, 2019·Psychiatry Research·Dawei XuZhiming Cui
Feb 23, 2019·Life Sciences·Ruyi ZhangShiping Ma
Aug 23, 2020·Neuroscience Letters·Jianying ShenZhihong Zheng
Nov 29, 2020·Journal of Ethnopharmacology·Ning JiangXinmin Liu