The antidepressant-like effects of Origanum majorana essential oil on mice through monoaminergic modulation using the forced swimming test

Journal of Traditional and Complementary Medicine
Saeid Abbasi-MalekiRahim Taghizad-Farid

Abstract

Origanum majorana (L.) is an herb used in the treatment of diseases related to the nervous system in traditional medicine (e.g. as an anticonvulsant and sedative). The present study was conducted to investigate the antidepressant-like effects of Origanum majorana essential oil (OMEO) on mice in the forced swimming test (FST). The animals were intraperitoneally (i.p.) injected with OMEO (10-80 mg/kg) 1 h before the FST. To assess the involvement of the monoaminergic system in the antidepressant activity of OMEO, different pharmacological antagonists were administered 15 min before OMEO administration (80 mg/kg). The administration of OMEO (40 and 80 mg/kg, i.p.) decreased immobility time and increased swimming and climbing times significantly. OMEO did not cause any changes in spontaneous locomotor function in the open-field test (OFT). The pre-treatment of the animals with SCH23390, sulpiride, haloperidol, WAY100135, p-chlorophenylalanine (pCPA), ketanserin, prazosin, yohimbine, reserpine, but not propranolol, inhibited the anti-immobility effect of OMEO in the FST. A combination of sub-effective doses of fluoxetine (5 mg/kg, i.p.) or imipramine (5 mg/kg, i.p.) with OMEO (10 mg/kg, i.p.) increased the antidepressant-like effect...Continue Reading

Citations

Apr 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Godfried Dougnon, Michiho Ito
Oct 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nan ZhangLei Yao
Oct 18, 2020·Brain Sciences·Nurul Uyun Abdul AzizMohamad Taufik Hidayat Baharuldin
Mar 2, 2021·Frontiers in Psychiatry·Mohamed H AlegiryAbdelfatteh El Omri
May 28, 2021·Phytotherapy Research : PTR·Atefeh JalaliMohammad M Zarshenas
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Amr FaroukNajla Albaridi

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