The antidiabetic and antilipidemic effects of Hibiscus sabdariffa: A systematic review and meta-analysis of randomized clinical trials.

Food Research International
Mohammed BuleMohammad Abdollahi

Abstract

Hibiscus sabdariffa (HS) is a woody-based subshrub of the Malvaceae family which has various uses in traditional medicine. This review systematically evaluates the evidence from clinical trials on the antidiabetic activity of HS. A random-effects model was used to obtain summary estimates. Five outcome measure, including fasting plasma glucose (FPG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoproteins (LDL), and triglyceride (TG) were assessed in the study. The results of the overall pooled statics for the FPG level showed that there was a significant reduction in FPG (WMD = -3.964 mg/dL; 95% CI: -6.227 to -1.702 and P-value was 0.001) and in the level of LDL (WMD = -7.843 mg/dL; 95% CI: -14.337 to -1.350 and P-value was 0.018). However, the pooled estimate showed that there was no statistically significant change on the TC (WMD = -30.382 mg/dL; 95% CI: -66.752 to 5.989 and P value was 0.102), the HDL (WMD = 0.074 mg/dL; 95% CI: -1.986 to 2.135 and P value was 0.944) and the TG (WMD = -9.050 mg/dL; 95% CI, -30.819 to 12.719 and P value was 0.102) compared to the placebo. Egger's weighted regression P values suggested that there was no potential publication bias in the FPG (P = 0.664), HDL (P = 0.065...Continue Reading

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Citations

May 2, 2020·Biomedicines·Jeannett A Izquierdo-VegaEduardo Madrigal-Santillán
Sep 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wamidh H TalibIntisar Hadi Al-Yasari
Jul 13, 2021·Journal of Ethnopharmacology·Mohammad Sadegh Adel MehrabanBagher Larijani

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