PMID: 7027750Jan 1, 1981Paper

The antidiabetic effect and pharmacokinetic properties of glipizide. Comparison of a single dose with divided dose regime

Acta Medica Scandinavica
J OstmanL Weiner

Abstract

In 13 patients with maturity-onset diabetes mellitus which did not respond to diet therapy alone, serum concentration of glipizide, blood glucose (B-G) concentration, serum immunoreactive insulin (S-IRI) and plasma glycerol (P-G) were monitored hourly over 12 hours after placebo, an initial dose of glipizide (5 mg p.o.) and long-term treatment with glipizide (range 7.5--20 mg, mean 10.4), which produced fasting B-G of less than 8 mmol/l. During the long-term treatment, glipizide was given in a random, cross-over pattern, either as a single dose in the morning or as a three-part divided dose regime, in the same total daily amount. The duration of the immediate effects of glipizide on B-G, S-IRI and S-IRI/B-G was 9, 4.5 and 6.5 hours, respectively. The mean apparent half-life of glipizide was 4.1 hours, the mean distribution volume 0.13 l/kg and the mean plasma clearance 0.023 l/kg x h. The area under the concentration curve from 7.30 a.m. to 7.30 p.m. was 15% higher after the single dose regime. The serum levels of glipizide at 10 hours were only 30% lower than after the three-part divided dose regime. There were no significant differences between the single and divided dose regimes as regards B-G, S-IRI and S-IRI/B-G, although ...Continue Reading

References

Jan 15, 1975·Biochemical Pharmacology·M J Crooks, K F Brown
Jan 1, 1979·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·D R OwensC D Davies
Nov 9, 1978·Nature·M N Feinglos, H E Lebovitz
Jan 1, 1975·European Journal of Clinical Pharmacology·L BalantG R Zahnd

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Citations

Jan 1, 1985·The Diabetes Educator·D E Baker, R K Campbell
Jan 1, 1986·European Journal of Clinical Pharmacology·E Wåhlin-BollA Melander
Dec 1, 1989·Journal of Clinical Pharmacology·W A KradjanF J Wood
Oct 6, 2020·The Journal of Toxicological Sciences·Norimichi HattoriYoshiro Saito

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