Oct 1, 1977

The antidysrhythmic aminosteroid, ORG 6001, reduces the ST-segment elevation produced by coronary occlusion in the dog

British Journal of Pharmacology
R J Marshall, J R Parratt


ST-segment elevation following temporary coronary artery occlusion was measured from nine epicardial leads in open-chest anaesthetized dogs. This was greatly reduced by the prior administration of the anti-dysrhythmic aminosteroid, ORG 6001. It is suggested that this effect is related either to a reduction in the extent and degree of myocardial ischaemia or to prevention of K+ egress from ischaemic cells.

Mentioned in this Paper

Coronary Occlusion
Administration Procedure
Myocardial Ischemia
Coronary Arteriosclerosis
Anterior Thoracic Region
Cardiac Depressants
Org 6001

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