The antiemetic interaction of Delta9-tetrahydrocannabinol when combined with tropisetron or dexamethasone in the least shrew.

Pharmacology, Biochemistry, and Behavior
Yaozhi WangNissar A Darmani

Abstract

5-HT3 receptor antagonists (e.g. tropisetron) combined with dexamethasone are effective for the acute phase of cisplatin (CIS)-induced emesis. This study determined the possible additive or synergistic antiemetic efficacy of Delta9-THC when combined with tropisetron or dexamethasone (DEX). Delta9-THC (0-10 mg/kg i.p.) was injected in combination with tropisetron (0-5 mg/kg i.p.) or dexamethasone (0-20 mg/kg i.p.) prior to CIS (20 mg/kg i.p.) in the least shrew, and the induced emesis was recorded for 60 min. CIS-induced vomiting was dose-dependently and significantly attenuated by individual administration of Delta9-THC (59-97% reductions) and tropisetron (79-100% attenuation), but not dexamethasone (26-40%), although a trend (p<0.1) towards reduced vomiting frequency following DEX was noted. Low doses of Delta9-THC (0.25 or 0.5 mg/kg) when combined with low doses of tropisetron (0.025, 0.1, or 0.25 mg/kg) were more efficacious in reducing emesis frequency than when given individually, but Delta9-THC had no antiemetic interactions with DEX. However, no tested combination provided a significantly greater effect on the number of animals vomiting than their individually-administered counterparts. The modest interaction of Delta9-T...Continue Reading

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Citations

Nov 5, 2013·European Journal of Pharmacology·Keith A SharkeyLinda A Parker
Dec 24, 2010·British Journal of Pharmacology·Linda A ParkerCheryl L Limebeer
Aug 11, 2016·Frontiers in Pharmacology·Erin M Rock, Linda A Parker
Jun 16, 2012·Pharmacology·Raquel AbaloMaría Isabel Martín-Fontelles
Jun 3, 2021·International Journal of Molecular Sciences·Weixia ZhongNissar A Darmani
Feb 2, 2010·Pharmacology & Therapeutics·Angelo A Izzo, Keith A Sharkey
Jul 14, 2010·Pharmacology & Therapeutics·Jutta WalstabBeate Niesler

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