The antiepileptic and neuroprotective effect of the Buxus hyrcana Pojark hydroethanolic extract against the pentylentetrazol induced model of the seizures in the male rats

The International Journal of Neuroscience
Vahid AziziAbdolkarim Hosseini

Abstract

The genus Buxus grows up widespread in Europe and Western Asia. It is an important traditional plant that has been used in the treatment of many illnesses. In the present study, the effect of hydroethanolic extract of Buxus hyrcana Pojark (BHP) on the animal model of seizure was studied. In this experimental study, 42 male Wistar rats weighing 220-250 g were randomly selected and were divided into experimental and control groups (six rats per group). The experimental groups were treated by the intraperitoneal (i.p.) single injection of 150, 300, 450, 600 and 750 mg kg-1 of hydroalcoholic extracts of BHP. The control negative group received normal saline (0.9%) and the control positive group received phenobarbital (30 mg kg-1, i.p.) pre-treatment. Thirty minutes after the treatments, the seizure behaviors were evaluated by the pentylenetetrazole (PTZ) (70 mg kg-1, i.p.) challenge. In addition, after the experiment, the rats were put to death and their brains were removed for the histological study. The ANOVA demonstrated that compared to the control group, all the BHP doses delayed the initiation and duration of the tonic, colonic and tonic-colonic seizures and significantly reduced the tonic and colonic seizures (p < 0.001). Fu...Continue Reading

References

Jun 28, 2003·Journal of Natural Products·M Iqbal ChoudharyMasood Parvez
Oct 20, 2006·Steroids·Zaheer Uddin BabarMohammad Hadi Meshkatalsadat
Dec 29, 2006·Chemistry & Biodiversity·M Iqbal ChoudharyUNKNOWN Atta-ur-Rahman
Jun 16, 2007·Seizure : the Journal of the British Epilepsy Association·Sanjay N MandhaneT Rajamannar
Jun 4, 2008·Acta Neuropathologica·Zaafir S Kherani, Roland N Auer
Dec 9, 2008·Journal of Ethnopharmacology·Somayeh EsmaeiliNoor Rain Abdullah
Jul 28, 2010·Chemical Biology & Drug Design·M Ahmed MesaikAqeel Ahmad
Jan 11, 2011·Seizure : the Journal of the British Epilepsy Association·Gang LiHajo M Hamer
Jun 20, 2012·BMC Complementary and Alternative Medicine·Fariba KarimzadehAli Gorji
Feb 4, 2014·Pharmacology, Biochemistry, and Behavior·Lekha Saha, Amitava Chakrabarti
Dec 30, 2014·Oxidative Medicine and Cellular Longevity·Noemí Cárdenas-RodríguezLiliana Carmona-Aparicio
May 23, 2015·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Ali Reza Ebrahimzadeh BideskanMahmoud Hosseini
Dec 29, 2015·Epilepsy & Behavior : E&B·Alexander B KowskiMartin Holtkamp
Jan 10, 2016·Cold Spring Harbor Perspectives in Medicine·Roustem Khazipov
Jul 21, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Yiğit UyanıkgilOytun Erbaş

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