The antifertility effectiveness of a novel copper-containing composite used in intrauterine contraceptive devices and the releasing behavior of cupric ions contained in the composite in rats

Contraception
Xiangchi PengChengliang Xiong

Abstract

This study was conducted to investigate the antifertility effectiveness of a novel copper-containing composite used in intrauterine contraceptive devices (IUDs) that contain cupric chloride/silicon dioxide/poly(vinyl alcohol) (CuCl₂/SiO₂/PVA) and the releasing behavior of cupric ions in the composite into the serum and uterine fluid in rats. Two hundred and forty sexually mature female Sprague-Dawley rats were randomly divided into six groups: sham-operated control group (n=20), bulk copper group (Cu group, n=40), SiO₂/PVA group (n=40), CuCl₂/SiO₂/PVA groups I (n=40, copper ion was released from IUD at a rate of 5-10 mcg/220 mm² per day) and II (n=40, copper ion was released from IUD at a rate of 10-20 mcg/220 mm² per day), and normal control group (n=20). IUD was inserted into the uterus of rats after acclimatization of 1 week. At different time points after implantation of the IUDs, cupric ion concentrations were measured in the serum and local uterine fluid in each group by flame atomic absorption, respectively. After 30 days of insertion, half of the rats in each group were mated with fertile male rats, and the antifertility rates were observed at 14 days of pregnancy. After the IUDs were removed, the remaining rats in each...Continue Reading

References

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