PMID: 6110721Nov 1, 1980Paper

The antifibrillatory potency of aprindine, mexiletine, tocainide and lignocaine compared on Langendorff-perfused hearts of rabbits and guinea-pigs

The Journal of Pharmacy and Pharmacology
A A Almotrefi, J B Baker

Abstract

The effectiveness of three new antiarrhythmic drugs, aprindine, mexiletine and tocainide in elevating ventricular fibrillation threshold measured in the Langendorff-perfused rabbit heart and in protecting against ouabain-induced arrhythmias in the Langendorff-perfused guinea-pig heart has been compared with that of lignocaine. All these drugs have produced a significant rise in the threshold but quantitatively mexiletine was about equal to, tocainide five times less and aprindine thirty-eight times more potent than lignocaine in this effect. Aprindine differed from the other three drugs in that it had a slow onset of action and its effect was not entirely removed upon reperfusion with the drug-free solution. Only aprindine and mexiletine provided complete protection against ouabain-induced ventricular fibrillation while 3 of 6 and 4 of 6 hearts fibrillated in the presence of lignocaine or tocainide respectively.

References

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Citations

Jan 1, 1984·Pharmacology & Therapeutics·E Winslow
Aug 25, 2015·Fundamental & Clinical Pharmacology·Abdulrahman A AlmotrefiMohammad S Alhumayyd
May 1, 1985·British Journal of Pharmacology·J P Trzeciakowski

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