PMID: 3745871Sep 1, 1986Paper

The antifilarial activity of a novel group of organic arsenicals upon Brugia pahangi

Journal of Helminthology
D A DenhamE A Friedheim

Abstract

Mel W is a second generation anionic organic arsenical which is filaricidal but has sporadic and unacceptable lethal side effects. Eight new cationic derivatives have now been synthesized in an attempt to avoid the side effects and have been examined for their effects upon adult Brugia pahangi in Meriones unguiculatus. They were all shown to be potent filaricides and the two best compounds, Mel Ga and Mel Cy, were at least 95% effective in killing adult B. pahangi at 5 X 3.13 mg/kg when injected subcutaneously.

References

Jan 1, 1979·Transactions of the Royal Society of Tropical Medicine and Hygiene·D A DenhamS C Skippins
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·L G Goodwin
Feb 1, 1962·Annals of Internal Medicine·O S HAYWARD

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