The antigen presentation pathway in medullary thymic epithelial cells, but not that in cortical thymic epithelial cells, conforms to the endocytic pathway

European Journal of Immunology
M KasaiT Mizuochi

Abstract

Murine medullary thymic epithelial cells (mTEC), but not cortical thymic epithelial cells (cTEC), are able to present a soluble antigen, ovalbumin, to helper T cells (Mizuochi, T. et al., J. Exp. Med. 1992. 175: 1601-1605). This functional difference between the mTEC and the cTEC is particularly important when we consider the thymic selection of the T cell repertoire. In the previous report, we proposed that mTEC and cTEC utilize two distinct antigen processing/presenting pathways (Kasai, M. et al., Eur. J. Immunol. 1996. 26: 2101-2107). In this report, we further confirmed this difference by analyzing (a) localization of MHC class II, H2-DM, and invariant chain (li) molecules, (b) the biochemical nature of MHC class II molecules, (c) the sensitivity of MHC class II alphabeta heterodimer formation to concanamycin A, a vacuolar H+-ATPase inhibitor, and (d) the subcellular distribution of MHC class II, H2-DM, and li molecules, in both TEC. Our results demonstrated that, in the mTEC, MHC class II, H2-DM and li molecules gain access to the endocytic pathway, where the luminal condition is acidic and thus li molecules are efficiently degraded and H2-DM molecules function well. In the cTEC, however, such molecules seemed to gain acce...Continue Reading

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Citations

Mar 14, 2000·Current Opinion in Immunology·L Klein, B Kyewski
Mar 29, 2002·Immunology·John H Robinson, Alexei A Delvig
Jan 6, 2005·Molecular and Cellular Biology·Saijai CheunsukChristopher L Bowlus
Nov 17, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michiyuki KasaiToshiaki Mizuochi
Feb 19, 2020·PLoS Biology·Robin A WelshScheherazade Sadegh-Nasseri
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paula R MengesAndrea J Sant
Jun 18, 2016·Mediators of Inflammation·José E BelizárioJean Pierre Peron
Jul 27, 2001·Archives of Physiology and Biochemistry·T MarinovaY Pomakov
Sep 13, 2003·Immunological Reviews·Jason GillRichard Boyd
Oct 7, 2015·Frontiers in Immunology·Sachiko Hirosue, Juan Dubrot
Oct 8, 2014·Immunology and Cell Biology·Alisha W BronietzkiIngo Schmitz
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Richard J MellanbyElizabeth K Bikoff
Nov 14, 2018·Immunogenetics·Mollie M Jurewicz, Lawrence J Stern

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