The antigen-presenting cell function of Reed-Sternberg cells

Leukemia & Lymphoma
J DelabieC De Wolf-Peeters

Abstract

Reed-Sternberg cells, the neoplastic cells of Hodgkin's disease, express all membrane molecules required to function as antigen-presenting cells (APCs), such as major histocompatibility complex (MHC) class II antigens and the recently characterized B7 proteins, which are of critical importance for APC to adequately stimulate CD4+ T cells. As APC do, Reed-Sternberg cells also express the adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58), via which T cells are able to adhere to the cell. MHC antigens, B7 proteins as well as the adhesion molecules are expressed by Reed-Sternberg cells in virtually all cases of Hodgkin's disease, irrespective of the subtype. In vitro studies have shown that Hodgkin's disease-derived cell lines are potent stimulators of mixed lymphocyte cultures and that the MHC antigens, B7 proteins and the adhesion molecules, expressed by Hodgkin's disease-derived cell lines, are essential for such a function. Taken together, these data strongly suggest that Reed-Sternberg cells function as APC in vivo, and that the APC function of the cell is a major common denominator of Hodgkin's disease. The APC function of Reed-Sternberg cells does not support the hypothesis that they derive from dendritic cells, since activa...Continue Reading

References

Jun 1, 1977·The Journal of Pathology·A E StuartJ A Habeshaw
Oct 1, 1992·Clinical and Experimental Immunology·P A EllisH B Angus
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C D GimmiL M Nadler
Sep 1, 1991·The Journal of Experimental Medicine·P S LinsleyJ A Ledbetter
Jan 1, 1992·International Review of Experimental Pathology·E MaggiS Romagnani
Mar 1, 1991·The Journal of Experimental Medicine·L KoulovaB Dupont
Feb 23, 1989·The New England Journal of Medicine·L M WeissJ Sklar
Apr 11, 1985·Nature·A Lanzavecchia
Oct 1, 1986·Human Pathology·L M WeissJ Sklar
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·V A BoussiotisL M Nadler
Jul 1, 1994·Immunology Today·W J Pichler, T Wyss-Coray
Jul 1, 1994·Immunology Today·C H JuneC B Thompson
Jan 1, 1993·European Journal of Immunology·D M Sansom, N D Hall
Mar 1, 1993·The Journal of Experimental Medicine·M AzumaL L Lanier
Nov 4, 1993·Nature·M AzumaC Somoza
Jul 1, 1994·The Journal of Experimental Medicine·A N Houghton
May 1, 1994·The American Journal of Surgical Pathology·D Y MasonN L Harris

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Citations

May 23, 2002·International Journal of Radiation Oncology, Biology, Physics·Matjaz ZwitterElizabeth D Robinton
Aug 29, 1998·British Journal of Haematology·I ChristiansenT H Tötterman
Mar 1, 1996·The American Journal of Surgical Pathology·J DelabieD D Weisenburger
Jun 7, 2005·Lancet·Paolo Corradini, Lucia Farina
Jul 23, 2013·Seminars in Cancer Biology·Yuxuan LiuAnke van den Berg
Dec 29, 2004·Leukemia & Lymphoma·Donatella AldinucciAntonio Pinto
Sep 11, 2002·American Journal of Clinical Pathology·William G MoriceJeffrey L Myers
Feb 13, 2002·The American Journal of Pathology·Donatella AldinucciAntonio Pinto

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