The Antigen Presenting Potential of CD21low B Cells.

Frontiers in Immunology
Marlene E ReinckeBaerbel Keller

Abstract

Human CD21low B cells are expanded in autoimmune (AI) diseases and display a unique phenotype with high expression of co-stimulatory molecules, compatible with a potential role as antigen-presenting cells (APCs). Thus, we addressed the co-stimulatory capacity of naïve-like, IgM-memory, switched memory and CD27negIgDneg memory CD21low B cells in allogenic co-cultures with CD4 T cells. CD21low B cells of patients with AI disorders expressed high levels of not only CD86, CD80, and HLA-DR (memory B cells) but also PD-L1 ex vivo and efficiently co-stimulated CD4 T cells of healthy donors (HD), as measured by upregulation of CD25, CD69, inducible co-stimulator (ICOS), and programmed cell death protein 1 (PD-1) and induction of cytokines. While the co-stimulatory capacity of the different CD21low B-cell populations was over all comparable to CD21pos counterparts of patients and HD, especially switched memory CD21low B cells lacked the increased capacity of CD21pos switched memory B-cells to induce high expression of ICOS, IL-2, IL-10, and IFN-γ. Acknowledging the limitation of the in vitro setting, CD21low B cells do not seem to preferentially support a specific Th effector response. In summary, our data implies that CD21low B cells o...Continue Reading

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Citations

Jan 19, 2021·Clinical and Experimental Immunology·H Rincón-ArévaloD Castaño
Jun 26, 2021·Frontiers in Immunology·Rick WilbrinkGwenny M Verstappen
Jun 26, 2021·Frontiers in Immunology·Wenhan DuLiwei Lu

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Methods Mentioned

BETA
FACS
flow cytometry
FCS
Assay

Software Mentioned

LEGENDplex

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