PMID: 6404188Mar 1, 1983Paper

The antigens of Paragonimus westermani, Schistosoma mansoni, and Fasciola hepatica adult worms. Evidence for the presence of cross-reactive antigens and for cross-protection to Schistosoma mansoni infection using antigens of Paragonimus westermani

The American Journal of Tropical Medicine and Hygiene
G V Hillyer, A E Serrano

Abstract

The presence of cross-reacting antigens between Paragonimus westermani, Schistosoma mansoni, and Fasciola hepatica adult worms was demonstrated by Ouchterlony immunodiffusion and enzyme-linked immunosorbent assay (ELISA). A serum bank was developed against the three trematode genera to serve as probes to determine the presence of cross-reacting antibodies to P. westermani worm extracts. In this manner, it was possible to demonstrate that antigens common to F. hepatica and S. mansoni tegument were also present in P. westermani worm extracts. Likewise, it was possible to demonstrate that the F. hepatica antigens which bind to Concanavalin A, as well as the subfraction which in isoelectric focusing has a pI of 4.2, were also found in P. westermani worms. Also, a monospecific polyclonal serum to a Fasciola/Schistosoma cross-reacting antigen and the anti-P. westermani serum both reacted in Ouchterlony immunodiffusion with the P. westermani antigenic extract, each producing a line which linked with each other indicating common antigenic determinants and suggesting a common antigen among the digenetic trematodes. Finally, the P. westermani antigenic extracts induced in mice the production of antibodies which reacted with S. mansoni ad...Continue Reading

Citations

Jun 1, 1989·Kisaengch'unghak chapchi. The Korean journal of parasitology·S H LeeJ Y Chai
Mar 1, 1989·Kisaengch'unghak chapchi. The Korean journal of parasitology·K H JooH J Rim
Jul 26, 2003·The Journal of Parasitology·Ana M Espino, George V Hillyer
Dec 1, 1983·Kisaengch'unghak chapchi. The Korean journal of parasitology·Suk Il KimSeung Yull Cho
Feb 3, 2015·PLoS Neglected Tropical Diseases·Catherine A GordonDonald P McManus
Mar 1, 1989·Kisaengch'unghak chapchi. The Korean journal of parasitology·K H JooH J Rim
Dec 1, 1986·Kisaengch'unghak chapchi. The Korean journal of parasitology·Ok Ran Lee, Jae Kyung Chang
Nov 1, 2001·Diagnostic Microbiology and Infectious Disease·S CarnevaleS O Angel
Jun 1, 1984·Veterinary Parasitology·G V Hillyer
Jul 1, 1991·International Journal for Parasitology·I IndrawatiY Ruangkunaporn

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