The antigonadotropic activity of Lithospermum ruderale. II. The inhibition of LRF-induced gonadotropin release in vitro

Contraception
W E Findley

Abstract

The antigonadotropic activity of lithosperm extracts was investigated at the pituitary level. When lithosperm extracts were added to primary pituitary cell cultures, LRF-stimulated LH release was inhibited. The cellular LH content was reduced but basal release was not significantly affected. These results suggest that lithosperm acts to directly inhibit the ability of LRF to stimulate LH release from the gonadotropes and the ability of the gonadotropes to produce LH.

References

Oct 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·F X GASSNERS G SUNDERWIRTH

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Citations

Aug 8, 2002·Phytotherapy Research : PTR·Xin ChenM Zack Howard
Jun 7, 2016·Biochemical and Biophysical Research Communications·Yu HeBanghao Zhu
Apr 9, 2004·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·T Benie, M L Thieulant
Aug 14, 2003·Phytotherapy Research : PTR·T BenieM-L Thieulant

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