PMID: 6106461Jan 1, 1980Paper

The antihypertensive action of beta-adrenoceptor blocking agents

Archives Internationales De Pharmacodynamie Et De Thérapie
J Conway

Abstract

The fall in blood pressure after the induction of beta-blockade occurs approximately 3 hours after the fall in cardiac output, heart rate and plasma renin activity has occurred. None of the known pharmacological actions of these agents can directly account for the fall in pressure. Further work is required to determine whether the fall in cardiac output is essential or whether these agents affect renal handling of sodium. Studies are also needed of baroceptor function as blood pressure falls.

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