PMID: 6989682Jan 1, 1980Paper

The antihypertensive and biochemical effects of hydrochlorothiazide/amiloride (Moduretic) versus chlorthalidone

The Journal of International Medical Research
F van Soeren


In an open two-period crossover study hydrochlorothiazide/amiloride and chlorthalidone were compared with regard to their anti-hypertensive and biochemical properties in ambulatory patients with mild to moderate hypertension. Twenty-five out of twenty-six patients completed the study. In the chlorthalidone group plasma potassium was consistently lower than in the hydrochlorothiazide/amiloride group, the difference achieved significance at 8 and 12 weeks after the start of treatment. With regard to the hypertension and other parameters no statistically significant differences were found.


Jan 9, 2009·The Journal of Clinical Hypertension·William J Elliott, Richard H Grimm
Apr 27, 2012·The Journal of Clinical Hypertension·Barry L Carter

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