The antimalarial resistome - finding new drug targets and their modes of action.

Current Opinion in Microbiology
Krypton Carolino, Elizabeth A Winzeler

Abstract

To this day, malaria remains a global burden, affecting millions of people, especially those in sub-Saharan Africa and Asia. The rise of drug resistance to current antimalarial treatments, including artemisinin-based combination therapies, has made discovering new small molecule compounds with novel modes of action an urgent matter. The concerted effort to construct enormous compound libraries and develop high-throughput phenotypic screening assays to find compounds effective at specifically clearing malaria-causing Plasmodium parasites at any stage of the life cycle has provided many antimalarial prospects, but does not indicate their target or mode of action. Here, we review recent advances in antimalarial drug discovery efforts, focusing on the following 'omics' approaches in mode of action studies: IVIEWGA, CETSA, metabolomic profiling.

Citations

Nov 26, 2020·Molecular Microbiology·Manish KumarManoj T Duraisingh
Jan 29, 2021·Frontiers in Microbiology·Xinyu YuJun Cao
Feb 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valery M DembitskyVladimir V Poroikov
Feb 24, 2021·Journal of Medicinal Chemistry·Aloysus LawongMargaret A Phillips
May 30, 2021·Nature Communications·Kevin CheesemanJonathan B Weitzman
May 19, 2021·Trends in Parasitology·Maëlle DuffeyDidier Leroy
May 18, 2021·Chembiochem : a European Journal of Chemical Biology·Kuan-Yi LuEmily R Derbyshire
Sep 16, 2021·ACS Infectious Diseases·Barbara ForteIan H Gilbert

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Methods Mentioned

BETA
metabolomic profiling
pull-down
pull-downs
immunoprecipitation
thermal shift
AlphaLISA
RNA-seq

Software Mentioned

Malaria Cell Atlas
CETSA
IVIEWGA

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

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