The Antimicrobial Activity of Annona emarginata (Schltdl.) H. Rainer and Most Active Isolated Compounds against Clinically Important Bacteria

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Juan G DolabRicardo D Enriz

Abstract

Annona emarginata (Schltdl.) H. Rainer, commonly known as "arachichú", "araticú", "aratigú", and "yerba mora", is a plant that grows in Argentina. Infusions and decoctions are used in folk medicine as a gargle against throat pain and for calming toothache; another way to use the plant for these purposes is chewing its leaves. Extracts from bark, flowers, leaves, and fruits from A. emarginata were subjected to antibacterial assays against a panel of Gram (+) and Gram (-) pathogenic bacteria according to Clinical and Laboratory Standards Institute protocols. Extracts from the stem bark and leaves showed moderate activity against the bacteria tested with values between 250⁻1000 µg/mL. Regarding flower extracts, less polar extracts (hexane, dichloromethane) showed very strong antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus ATCC 43300 with values between 16⁻125 µg/mL. Additionally, hexane extract showed activity against Klebsiella pneumoniae (MIC = 250 µg/mL). The global methanolic extract of the fruits (MeOHGEF) was also active against the three strains mentioned above, with MICs values 250⁻500 µg/mL. Bioassay-guided fractionation of MeOHGEF led to the isolat...Continue Reading

References

Jul 1, 1986·Journal of Natural Products·M Nieto
Sep 15, 1988·Physical Review A: General Physics·A D Becke
Apr 6, 1999·Phytotherapy Research : PTR·A I WaechterA Fournet
Apr 11, 2000·Journal of Natural Products·J R IosetK Hostettmann
May 3, 2003·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·L P Santos PimentaM A D Boaventura
Oct 3, 2003·Journal of Ethnopharmacology·Gabriela Egly FeresinGuillermo Schmeda-Hirschmann
Dec 23, 2004·Journal of Agricultural and Food Chemistry·Jong H KimRussell J Molyneux
Nov 16, 2005·Natural Product Research·Jacqueline A TakahashiLuiz G F E Silva
Mar 17, 2007·Natural Product Research·Olga Alvarez ColomAlicia Bardon
Jul 28, 2007·Fitoterapia·Francesca FainiFranco Delle Monache
Nov 28, 2007·Journal of Agricultural and Food Chemistry·Fabricio BisognoRicardo Enriz
Jan 12, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomas GonecJosef Jampilek
Mar 31, 2015·Bioorganic & Medicinal Chemistry·Jiri KosJosef Jampilek
Jul 18, 2015·Bioorganic & Medicinal Chemistry·Jiri KosJosef Jampilek

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Citations

Aug 9, 2018·International Journal of Molecular Sciences·Sarka PospisilovaJosef Jampilek
Jun 5, 2019·Medicinal Chemistry·Robert Musiol
Sep 13, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jiri KosJosef Jampilek
Jan 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wioleta CieslikRobert Musiol
Jul 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Annabelle St-PierreIsabel Desgagné-Penix
Jul 25, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·F J Álvarez-MartínezV Micol
Aug 19, 2021·Chemistry & Biodiversity·Carolina Ovile MimiCarmen Silvia Fernandes Boaro

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Methods Mentioned

BETA
column chromatography

Software Mentioned

MOLEKEL
MEP
AXUN
Gaussian

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