The antimicrobial activity of lactoferrin: current status and perspectives

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Nicola Orsi

Abstract

Lactoferrin (Lf) is a multifunctional iron glycoprotein which is known to exert a broad-spectrum primary defense activity against bacteria, fungi, protozoa and viruses. Its iron sequestering property is at the basis of the bacteriostatic effect, which can be counteracted by bacterial pathogens by two mechanisms: the production of siderophores which bind ferric ion with high affinity and transport it into cells, or the expression of specific receptors capable of removing the iron directly from lactoferrin at the bacterial surface. A particular aspect of the problem of iron supply occurs in bacteria (e.g. Legionella) which behave as intracellular pathogens, multiplying in professional and non professional macrophages of the host. Besides this bacteriostatic action, Lf can show a direct bactericidal activity due to its binding to the lipid A part of bacterial LPS, with an associated increase in membrane permeability. This action is due to lactoferricin (Lfc), a peptide obtained from Lf by enzymatic cleavage, which is active not only against bacteria, but even against fungi, protozoa and viruses. Additional antibacterial activities of Lf have also been described. They concern specific effects on the biofilm development, the bacteri...Continue Reading

Citations

Nov 22, 2007·Advances in Therapy·Mohan Pammi VenkateshLeonard E Weisman
Sep 19, 2008·Current Gastroenterology Reports·Miguel M Cabada, A Clinton White
Jun 21, 2007·Chemical Communications : Chem Comm·Nunzio TuccittoGiovanni Marletta
Dec 6, 2011·Molecular & Cellular Proteomics : MCP·Yu-Hsuan HoChien-Sheng Chen
May 30, 2006·The Pediatric Infectious Disease Journal·Edith L G M TonnaerJo H A J Curfs
Oct 17, 2006·Clinical Microbiology Reviews·Holly M Scott Algood, Timothy L Cover
Aug 29, 2006·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Theresa J OchoaThomas G Cleary
Aug 29, 2006·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Veronica LopezBo Lönnerdal
Aug 29, 2006·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Nidia León-SicairosMireya de la Garza
Feb 16, 2012·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Héctor Flores-VillaseñorNidia Leon-Sicairos
Dec 23, 2011·International Journal of Dentistry·João Armando BrancherPaula Cristina Trevilatto
Mar 9, 2005·Respiration; International Review of Thoracic Diseases·Francesco BlasiStefano Aliberti
Jun 14, 2013·BMC Veterinary Research·Katarzyna Wojdak-MaksymiecTomasz Strabel
Jul 1, 2006·Clinical Medicine & Research·Nidia León-SicairosMireya de la Garza
Nov 5, 2013·International Journal of Molecular Sciences·Mena Abdel-NourCyril Guyard
Jan 21, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Fernando CarmonaJosé M Dominguez-Vera
Jun 9, 2009·Bioscience, Biotechnology, and Biochemistry·Celia ConesaLourdes Sánchez
Jun 18, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Christie G TurinUNKNOWN NEOLACTO Research Group
Jul 24, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Nidia León-SicairosAdrian Canizalez-Román
Jun 1, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Sarahí Luna-CastroMireya de la Garza
Jun 12, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Po-Wen ChenFang-Yi Chu
Jun 15, 2014·Current Microbiology·Maria I Quintero-VillegasRobert Hutkins
Mar 3, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Héctor Flores-VillaseñorJan G M Bolscher
Mar 17, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Agostina PietrantoniFabiana Superti
Apr 7, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Maria Grazia AmmendoliaFabiana Superti
Aug 4, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ashoka SreedharaGerd Elisabeth Vegarud
May 25, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Yifan LiuYizhen Wang
Dec 6, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Isui García-MontoyaQuintin Rascón-Cruz
Jan 12, 2011·European Journal of Pediatrics·Nehama LinderItzhak Levy
Jan 27, 2007·Journal of Pediatric Gastroenterology and Nutrition·James C KingRick de Waard
Sep 24, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Deepak SharmaOleti Tejo Pratap
Jul 25, 2013·Expert Review of Anti-infective Therapy·Krithika LingappanMohan Pammi
Jun 3, 2009·Expert Review of Anti-infective Therapy·Mohan Venkatesh, Steven Abrams
Aug 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Angélique LewiesDu Plessis Lissinda Hester
Sep 8, 2011·Expert Opinion on Drug Delivery·Hiraku Onishi
Jul 7, 2007·Drug Development and Industrial Pharmacy·Hiraku OnishiKenichi Koyama

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