PMID: 2499150May 1, 1989Paper

The antimycotic drug terbinafine in contrast to ketoconazole lacks acute effects on the pituitary-testicular function of healthy men: a placebo-controlled double-blind trial

Acta Endocrinologica
D NashanE Nieschlag

Abstract

Among the side-effects of the antimycotic drug ketoconazole, inhibition of testosterone biosynthesis is highly pronounced. The decrease in testosterone may cause impotence and gynecomastia, and this side-effect has been exploited in drug tests for the treatment of androgen-dependent tumours. Terbinafine, an allylamine derivate, from a new group of antifungal substances, did not show similar inhibiting effects on steroid synthesis in vitro and in vivo in animal experiments. In a double-blind, placebo-controlled study the influence of terbinafine and ketoconazole on the pituitary-testicular axis in normal young men were compared. Serial blood sampling for 12 h was followed by the ingestion of the placebo, ketoconazole (200 mg) or terbinafine (500 mg) on three different occassions in random order. Ketoconazole administration caused a steep decrease of serum testosterone reaching a nadir after 4-5 h. Simultaneously an increase in 17-hydroxyprogesterone occurred with peak values after 5 h. During 12 h after the administration of ketoconazole no changes in LH pulse frequency and amplitude were found, although testosterone serum levels were in the subnormal range for about 8-9 h. Terbinafine showed no effects on testosterone and 17-hy...Continue Reading

Associated Clinical Trials

May 28, 2014·William Bremner

Citations

Mar 16, 2012·European Journal of Clinical Pharmacology·Tsuneaki YoshizatoKyoichi Ohashi
Jul 30, 1999·Journal of the American Academy of Dermatology·A K GuptaN H Shear
Jun 26, 2002·Biological & Pharmaceutical Bulletin·Cicero Lee-Tian Chang, Hang-Poung Fung
Feb 4, 1998·Veterinary Surgery : VS·J DahlingerJ Bea
Sep 7, 1995·The New England Journal of Medicine·A KeoghA Kaan
Apr 1, 1997·The Annals of Pharmacotherapy·S M Abdel-Rahman, M C Nahata

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