The antinociceptive and anti-inflammatory activities of Piptadenia stipulacea Benth. (Fabaceae)

Journal of Ethnopharmacology
Aline Cavalcanti de QueirozMagna Suzana Alexandre-Moreira

Abstract

In this study, we attempted to identify the possible antinociceptive and anti-inflammatory actions of the aqueous phase, the ethyl acetate phase and one unknown flavonoid obtained from aerial parts of Piptadenia stipulacea, known in Brazil as "jurema-branca", "carcará" and "rasga-beiço". Aerial parts of Piptadenia stipulacea were used and after fractionation, the flavonoid FGAL was obtained. Experiments were conducted on Swiss mice using the acetic acid-induced writhing test, the hot plate test, the formalin-induced pain test and zymosan A-induced peritonitis test. The aqueous and ethyl acetate phases (p.o., 100mg/kg); and the flavonoid FGAL (p.o. and i.p. at 100 micromol/kg), reduced the nociception produced by acetic acid, by 49.92%, 54.62%, 38.97% and 64.79%, respectively. In vivo inhibition of nociception by the ethyl acetate phase (100mg/kg, p.o.) in the hot plate test was favorable, indicating that this fraction exhibited central activity. The ethyl acetate phase (100mg/kg, p.o.) reduced the formalin effects in both phases by 28.51% and 55.72%, respectively. Treatment with the aqueous phase (100mg/kg, p.o.) and FGAL (100 micromol/kg, i.p.) only protected the second phase by 69.76% and 68.78%, respectively. In addition, it...Continue Reading

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Citations

Oct 12, 2012·Inflammopharmacology·Alessandra M V RitterCiomar A Bersani-Amado
Feb 22, 2013·Natural Product Research·Anne Dayse Soares da SilvaMagna Suzana Alexandre-Moreira
May 10, 2011·Journal of Medicinal Food·Mairim Russo SerafiniAdriano Antunes de Souza Araújo
Dec 17, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Alessandra Mileni Versuti RitterCiomar Aparecida Bersani-Amado
Nov 23, 2011·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Cibério Landim MacêdoBagnólia Araújo da Silva
Dec 2, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cibério L MacêdoBagnólia A da Silva
Dec 12, 2012·The Journal of Pharmacy and Pharmacology·Roberta Campos LinoElson Alves Costa
Sep 20, 2011·European Journal of Pharmacology·Flávia V Santa-CecíliaMarcelo H dos Santos
Jun 25, 2015·BMC Complementary and Alternative Medicine·Juliane C SilvaJackson Roberto G da S Almeida
Jan 11, 2012·Journal of Ethnopharmacology·Alejandra Cristina SaragustiMaría Gabriela Ortega
Feb 1, 2014·Natural Product Research·Aline Cavalcanti de QueirozMagna Suzana Alexandre-Moreira
Sep 27, 2013·Anais Da Academia Brasileira De Ciências·Iziara F FlorentinoElson A Costa
Dec 5, 2017·BMC Complementary and Alternative Medicine·Juliana da Nóbrega CarreiroBagnólia Araújo da Silva
Jul 28, 2016·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Êuder Reis DiasAlexsandro Branco
Mar 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiao LiZuojing Li
Oct 7, 2020·Journal of Ethnopharmacology·Lidiane Schultz BranquinhoCandida Aparecida Leite Kassuya
Nov 3, 2020·Journal of Ethnopharmacology·A Anand GanapathyAlaganandam Kumaran

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