The antinociceptive effects of intravenous tianeptine in colorectal distension-induced visceral pain in rats: the role of 5-HT₃ receptors

European Journal of Pharmacology
S Sirri BilgeTayfun I Uzbay

Abstract

Tianeptine is an unusual tricyclic antidepressant drug. In this study, we aimed to investigate the antinociceptive effect of tianeptine on visceral pain in rats and to determine whether possible antinociceptive effect of tianeptine is mediated by serotonergic (5-HT(2,3)) and noradrenergic (α(1,2)) receptor subtypes. Male Sprague Dawley rats (250-300 g) were supplied with a venous catheter, for drug administrations, and enameled nichrome electrodes, for electromyography, at external oblique musculature. Colorectal distension (CRD) was employed as the noxious visceral stimulus and the visceromotor response (VMR) to CRD was quantified electromyographically before and 5, 15, 30, 60, 90 and 120 min after tianeptine administration. Antagonists were administered 10 min before tianeptine for their ability to change tianeptine antinociception. Intravenous administration of tianeptine (2.5-20 mg/kg) produced a dose-dependent reduction in VMR. Administration of 5-HT(3) receptor antagonist ondansetron (0.5, 1 and 2 mg/kg), but not 5-HT(2) receptor antagonist ketanserine (0.5, 1 and 2 mg/kg), reduced the antinociceptive effect of tianeptine (10mg/kg). In addition, administration of α(1)-adrenoceptor antagonist prazosin (1 mg/kg) or α(2)-adr...Continue Reading

References

Jan 1, 1990·Neuropharmacology·C M FattacciniM Hamon
Feb 26, 1990·Brain Research·S R GlaumE G Anderson
Nov 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·T MenniniS Garattini
Jan 1, 1986·Current Medical Research and Opinion·J G MacfarlaneE M Grace
May 5, 1999·Life Sciences·I T UzbayI Tuglular
May 1, 2002·Behavioural Pharmacology·M Dziedzicka-WasylewskaJ Maj
Sep 6, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M O Rojas-CorralesJ A Micó
Feb 14, 2004·The Australian and New Zealand Journal of Psychiatry·Paulo S Muniz, Antonio E Nardi
Feb 24, 2004·Journal of Pharmacological Sciences·Erdem N DumanNesrin Erciyes
Apr 23, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·D A FishbainR S Rosomoff
Dec 14, 2004·Journal of Psychiatric Research·Mert CeyhanI Tayfun Uzbay
Jun 2, 2005·Pain·David J GoldsteinSmriti Iyengar
Aug 13, 2005·European Journal of Pain : EJP·Harald BreivikDerek Gallacher
Nov 18, 2005·Psychopharmacology·Tevfik AliciI Tayfun Uzbay
Nov 29, 2005·European Journal of Pain : EJP·Anne M McDermottEllen M Dukes
Jan 18, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tayfun UzbayNevzat Yüksel
Jun 10, 2006·Trends in Pharmacological Sciences·Juan A MicóAlain Eschalier
Jul 11, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tayfun I UzbayMert Ceyhan
Sep 11, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tayfun I Uzbay
Sep 27, 2008·Pharmacology, Biochemistry, and Behavior·Takayuki HayashiYoriko Kawakami
Jun 15, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Tiina Saarto, Phil J Wiffen

❮ Previous
Next ❯

Citations

Nov 19, 2013·PloS One·Emilia Horjales-AraujoLene Vase
Feb 20, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jardel Gomes VillarinhoJuliano Ferreira
Jul 14, 2012·Organic Letters·Navid DastbaravardehMarko D Mihovilovic
Sep 19, 2020·European Journal of Pharmacology·Tsukasa NozuToshikatsu Okumura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.