The antinociceptive response to nicotinic agonists in a mouse model of postoperative pain

Anesthesia and Analgesia
Thomas J RowleyPamela Flood

Abstract

Nicotine, the prototypical broad spectrum agonist at central nicotinic receptors, has analgesic action after surgery. Various subtype-specific nicotinic agonists have antinociceptive effects in animal models, but the response is highly dependent on the model tested. In an effort to determine what nicotinic subtypes might be targeted in future clinical studies, we tested agonists selective for alpha 4 beta 2 and alpha 7 containing nicotinic receptors in a mouse model of postoperative pain. After paw incision, mice were tested for heat latency and pressure threshold before and after treatment with a dose range of ligands selective for alpha 4 beta 2 and alpha 7 containing nicotinic receptors. To demonstrate that nicotine reduced nociceptive input in this model, the lumbar spinal cords of a subgroup of these mice were stained for the phosphorylated form if CREB. Nicotine and metanicotine (alpha 4 beta 2 selective) were fully effective as an analgesic in heat and pressure testing. The alpha 7 partial agonist GTS-21 significantly increased the heat latency after surgery, but did not alter pressure threshold. The alpha 7 selective antagonist methyllicaconitine decreased the efficacy of nicotine to increase heat latency but did not af...Continue Reading

References

Nov 21, 1994·Brain Research·M I DamajB R Martin
Mar 1, 1996·Pain·T J BrennanG F Gebhart
Apr 15, 1999·Annual Review of Neuroscience·A B MacDermottS A Siegelbaum
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·F van HaarenW R Kem
May 17, 2000·Pharmaceutica acta Helvetiae·R A Glennon, M Dukat
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·M Cordero-Erausquin, J P Changeux
Oct 2, 2001·The Journal of Physiology·A KiyosawaN Akaike
Feb 5, 2002·Journal of Neurophysiology·Esther M PogatzkiTimothy J Brennan
Jun 25, 2002·European Journal of Pharmacology·Caterina VirginioGeorg C Terstappen
Jul 20, 2002·Anesthesiology·Pamela FloodKristen M Coates
Aug 10, 2002·Anesthesiology·Xinhui Li, James C Eisenach
Sep 26, 2003·Anesthesiology·Esther M Pogatzki, Srinivasa N Raja
Apr 2, 2004·Journal of Neurochemistry·R Douglas ShytleJun Tan
Nov 27, 2004·Anesthesiology·Pamela Flood, Danette Daniel

❮ Previous
Next ❯

Citations

Oct 5, 2011·Psychological Bulletin·Joseph W DitreMary M Meagher
Nov 28, 2012·The Journal of Pain : Official Journal of the American Pain Society·Lisa C LoramLinda R Watkins
Jan 31, 2013·Journal of Neuroscience Research·Bogdan I TambaTudor Petreus
Mar 1, 2015·Neuropharmacology·Dimitris N XanthosPetra Scholze
Jul 13, 2016·BMC Complementary and Alternative Medicine·Geun Joo ChoiJi Wung Kwon
Oct 17, 2017·FEBS Letters·Arik J Hone, J Michael McIntosh
Sep 25, 2010·Anesthesiology·Yu ShiDavid O Warner
Oct 19, 2017·The Journal of Pharmacology and Experimental Therapeutics·S Lauren KyteDavid A Gewirtz
Aug 21, 2008·Anesthesia and Analgesia·Neal L Benowitz
Jan 5, 2014·Anesthesia and Analgesia·Basem M Mishriky, Ashraf S Habib
Oct 4, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Matthew SmuckMing-Chih J Kao
Sep 16, 2018·Scientific Reports·Camila HirotsuMonica Levy Andersen
Aug 22, 2021·Behavioural Pharmacology·Gail Winger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.