The antioxidant activity of allylpyrocatechol is mediated via decreased generation of free radicals along with escalation of antioxidant mechanisms

Phytotherapy Research : PTR
Debjani SarkarMitali Chatterjee

Abstract

Allylpyrocatechol (APC) is responsible for the antiinflammatory activity exhibited by the methanolic extract of leaves of Piper betle. As antiinflammatory compounds may display antioxidant properties and vice versa, we investigated the antioxidant effect of APC. APC effectively reduced phorbol-myristate-acetate-induced generation of reactive oxygen species and superoxide in murine peritoneal macrophages as well as inhibited Escherichia-coli-induced phagocytic activity of macrophages. Furthermore, pBluescript SK(+) plasmid DNA damage induced by addition of sodium ascorbate was attenuated by APC as it inhibited transformation of the supercoiled form to a relaxed form. In addition, APC increased the enzymatic (catalase) and nonenzymatic (GSH) antioxidant components of murine macrophages. Taken together, APC exhibited an antioxidant activity which was mediated both via decreased generation of free radicals along with increase in cellular antioxidants.

References

Feb 1, 1987·The Journal of Clinical Investigation·C F Nathan
Jan 1, 1983·Annual Review of Biochemistry·A Meister, M E Anderson
Jan 1, 1995·Journal of Pineal Research·R J ReiterD Acuña-Castroviejo
Jun 13, 1998·The American Journal of Clinical Nutrition·M NorooziM E Lean
Dec 22, 1999·Proceedings of the Society for Experimental Biology and Medicine·A C ChanD Chiu
Jun 23, 2000·Chemico-biological Interactions·T MiuraK Zhao
Jan 5, 2002·Physiological Reviews·Wulf Dröge
Apr 22, 2003·Chemical Research in Toxicology·Monica YazzieDiane M Stearns
May 26, 2005·Pharmacological Reviews·Vincenzo MollaceDaniela Salvemini
Sep 19, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·E Suzuki, K Umezawa
Nov 23, 2006·Journal of Agricultural and Food Chemistry·Jitesh S RatheeSubrata Chattopadhyay
May 26, 2007·The Journal of Pharmacy and Pharmacology·Sudipto GangulyMitali Chatterjee
Dec 19, 2007·Cell Research·Helena Lobo BorgesJean Y J Wang
Jun 11, 2009·Journal of Clinical Immunology·Nilanjana BanerjeeAshok K Giri
Sep 3, 2010·Phytotherapy Research : PTR·Lorenza SperanzaAlfredo Grilli

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Citations

Oct 17, 2013·Indian Journal of Pharmacology·Soumita DeMitali Chatterjee

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