The Antioxidant Activity of Pistachios Reduces Cardiac Tissue Injury of Acute Ischemia/Reperfusion (I/R) in Diabetic Streptozotocin (STZ)-Induced Hyperglycaemic Rats

Frontiers in Pharmacology
Rosanna Di PaolaSalvatore Cuzzocrea

Abstract

Diabetes mellitus is an important risk factor for the development of heart pathology. Myocardial infarction is the cause of death occurring after prolonged ischemia of the coronary arteries. Restoration of blood flow is the first intervention against heart attack, although the process of restoring blood flow to the ischemic myocardium could cause additional injury. This phenomenon, termed myocardial ischemia-reperfusion (MI-R) injury, is characterized by the formation of oxygen radicals. Pistachios have significant glucose- and insulin-lowering effects and can improve the inflammatory contest by downregulating both the expression and the circulating levels of several metabolic risk markers. The monocyte/macrophage cell line J774 was used to assess the extent of protection by natural raw (NP) and roasted salted (RP) pistachios against lipopolysaccharide (LPS)-induced inflammation. Moreover, antioxidant activity of NP and RP was assessed in anin vivomodel of paw edema in rats induced by carrageenan (CAR) injection in the paw. This study evaluates the antioxidant properties of pistachios on the inflammatory process associated with myocardial ischemia/reperfusion injury (I/R) in diabetic rats. Rats were pre-treated with either NP o...Continue Reading

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Citations

May 23, 2019·Canadian Journal of Physiology and Pharmacology·Dina M KhodeerAmani A Elbaz
Apr 5, 2020·Biology·Anastasia V PoznyakAlexander N Orekhov
Jun 3, 2021·Antioxidants·Marika CordaroVittorio Calabrese
Jun 3, 2021·International Journal of Molecular Sciences·Rosalba SiracusaRosanna Di Paola
Jul 3, 2021·International Journal of Molecular Sciences·Rosalba SiracusaRosanna Di Paola
Jul 3, 2021·International Journal of Molecular Sciences·Ramona D'AmicoRosanna Di Paola
Aug 8, 2021·International Journal of Molecular Sciences·Tiziana GenoveseRosanna Di Paola

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Methods Mentioned

BETA
biopsies
light microscopy
ELISA
enzyme-linked immunosorbent assay
nuclear translocation

Software Mentioned

Axio Vision
Optilab Graftek
Leica
Adobe Photoshop

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