PMID: 15225502Jul 1, 2004Paper

The antioxidant function of high density lipoproteins: a new paradigm in atherosclerosis

Revista española de cardiología
Marta TomásJaume Marrugat

Abstract

The one disease associated with the greatest morbidity and mortality in industrialized countries is coronary heart disease (CHD). High density lipoprotein (HDL) is one of the most important independent protective factors for the arteriosclerosis which underlies CHD. Paraoxonase 1 (PON1) is an enzyme that confers antioxidant properties to HDL. In vitro, PON1 hydrolyzes a large variety of endogenous or exogenous substrates, some of which are clearly involved in the progression of arteriosclerosis. A close relationship between PON1 deficiency and accelerated progression of arteriosclerosis has been found in animal models. Moreover, PON1 activity is reduced in high oxidative stress diseases such as CHD, dyslipoproteinemias, inflammatory processes, diabetes and certain neuropathies. Reduced PON1 enzyme activity is associated with several arteriosclerosis-related diseases. The most thoroughly studied genetic variant of PON1 is PON1-192, in which the R allele is associated with elevated paraoxonase activity. This allele, present in 24.8% of the Italian population, is found in up to 78.9% of the population of Ecuadorian Cayapa Indians. A metaanalysis of studies on the relationship between CHD and the R allele showed the latter to be an...Continue Reading

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Citations

Jul 21, 2012·Diabetes & Metabolic Syndrome·Sandhya Pillai NairUma Nayak
Jul 27, 2011·Environmental Toxicology and Pharmacology·Mariana Lucila FerramolaMaría Sofía Giménez
Aug 29, 2009·Revista española de cardiología·Antonio CocaUNKNOWN Representación del Grupo de los Investigadores del Estudio RIMHA
Sep 22, 2012·Toxicology and Applied Pharmacology·Mariana L FerramolaMaría S Giménez
Aug 7, 2013·Toxicology and Applied Pharmacology·Matías F F Pérez DíazMaría S Gimenez
May 22, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ranjana SinghGermaine Cornelissen
Aug 12, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Setor K Kunutsor
Dec 22, 2017·Journal of the Endocrine Society·Mark R BurgeDavid S Schade
Oct 23, 2015·Journal of Basic and Clinical Physiology and Pharmacology·Shiv Vardan SinghAnirban Pal

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