The antioxidant LY 231617 ameliorates functional and morphological sequelae induced by global ischemia in rats

Brain Research
F BlockM Schwarz

Abstract

In this study the effect of LY 231617, an antioxidant, on spatial learning deficit and on neuronal damage following transient cerebral ischemia was evaluated. Global ischemia was induced by four-vessel-occlusion (4VO) for 20 min in rats. LY 231617 (20 mg/kg i.p.) was administered after onset of reperfusion. One week after surgery spatial learning was tested in the Morris water maze. LY 231617 reduced the increase in escape latency and in swim distance induced by 4VO. Neuronal damage in the CAI sector of the hippocampus produced by 4VO was significantly attenuated by LY 231617. The present data demonstrate that posttreatment with LY 231617 exerts a protective effect on hippocampal neuronal damage and deficits in spatial learning induced by 4VO.

References

Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·C BromontJ Bralet
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
May 1, 1982·Annals of Neurology·W A PulsinelliF Plum
May 30, 1994·Behavioural Brain Research·J A NunnB S Meldrum
May 1, 1993·Stroke; a Journal of Cerebral Circulation·J A ClemensJ A Panetta

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Citations

Mar 7, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Fatih EkiciHasan Erdogan
Aug 2, 2002·Pharmacology, Biochemistry, and Behavior·Leticia F PettenuzzoMoacir Wajner
Apr 1, 1997·Pharmacology, Biochemistry, and Behavior·F Block, M Schwarz
May 26, 1999·Progress in Neurobiology·F Block
Mar 21, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D StephensonJ Clemens

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