The Antioxidant Rosmarinic Acid Ameliorates Oxidative Lung Damage in Experimental Allergic Asthma via Modulation of NADPH Oxidases and Antioxidant Enzymes.

Inflammation
Zhengmin LiangJiakang He

Abstract

Oxidative stress can induce lung damage and aggravate airway inflammation in asthma. Previously, we reported that rosmarinic acid (RA) exerted strong anti-inflammatory effects in a mouse allergic asthma model. Therefore, we hypothesized that RA might also have antioxidative effects in a superimposed asthma mouse model with oxidative lung damage challenged with ovalbumin (Ova) and hydrogen peroxide (H2O2). We evaluated the antioxidative and anti-asthmatic activity of RA and explored its possible mechanisms of action. Mice sensitized to Ova and challenged with Ova and H2O2 were treated with RA 1 h after challenge. RA treatment greatly diminished the number of inflammatory cells; decreased IL-4, IL-5, and IL-13 production; increased IFN-γ secretion; significantly downregulated ROS production; and markedly upregulated the activities of SOD, GPx, and CAT. Furthermore, RA treatment resulted in a significant increase in the expression of Cu/Zn SOD and a notable reduction in NOX-2 and NOX-4 expression in lung tissues. These findings suggest that RA may effectively alleviate oxidative lung damage and airway inflammation in asthma.

References

Dec 17, 2002·Phytochemistry·Maike Petersen, Monique S J Simmonds
Apr 1, 2006·American Journal of Respiratory Cell and Molecular Biology·Kyung Sun LeeYong Chul Lee
Apr 25, 2006·Journal of Photochemistry and Photobiology. B, Biology·Jitka PsotovaDaniela Walterova
Jan 24, 2007·Physiological Reviews·Karen Bedard, Karl-Heinz Krause
Jan 8, 2008·Antioxidants & Redox Signaling·Hisatoshi Sugiura, Masakazu Ichinose
Jan 9, 2008·Antioxidants & Redox Signaling·Tomoaki HoshinoHisamichi Aizawa
May 19, 2009·Archives of Toxicology·Arthur I CederbaumDefeng Wu
Jun 30, 2009·Phytochemistry·Maike PetersenStefan Wolters
Oct 1, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Chan-Sun ParkHee-Bom Moon
Nov 24, 2011·American Journal of Respiratory and Critical Care Medicine·Amanda SutcliffeChris E Brightling
Jan 17, 2012·Journal of Clinical Biochemistry and Nutrition·Masato KatsuyamaChihiro Yabe-Nishimura
Mar 24, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiao ChuJiakang He
May 29, 2012·Free Radical Biology & Medicine·Wanxing Eugene HoW S Fred Wong
Mar 26, 2014·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Suhuan LiYiqun Zhang
Oct 8, 2014·Experimental and Therapeutic Medicine·Xia ChenXiao-Xi Chen
Jan 27, 2015·Applied Microbiology and Biotechnology·Gun-Dong KimCheung-Seog Park
Feb 7, 2016·The International Journal of Biochemistry & Cell Biology·Ahmed NadeemSheikh F Ahmad
Jun 16, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhengmin LiangJiakang He
Aug 17, 2016·The Journal of Experimental Medicine·Keer SunDennis W Metzger
Nov 9, 2016·International Immunopharmacology·Zhengmin LiangJiakang He
Dec 26, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mahboobeh Ghasemzadeh RahbardarHossein Hosseinzadeh
Jul 5, 2017·Canadian Journal of Physiology and Pharmacology·Parisa Hasanein, Rosa Seifi
Jul 28, 2018·Viruses·Olga A KhomichAlexander V Ivanov

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
Bronchoalveolar Lavage
bronchoalveolar
lavage
PCR

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