The Antioxidative Function of Alpha-Ketoglutarate and Its Applications

BioMed Research International
Shaojuan LiuKang Yao

Abstract

Alpha-ketoglutarate (AKG) is a crucial intermediate of the Krebs cycle and plays a critical role in multiple metabolic processes in animals and humans. Of note, AKG contributes to the oxidation of nutrients (i.e., amino acids, glucose, fatty acids) and then provides energy for cell processes. As a precursor of glutamate and glutamine, AKG acts as an antioxidant agent as it directly reacts with hydrogen peroxide with formation of succinate, water, and carbon dioxide; meanwhile, it discharges plenty of ATP by oxidative decarboxylation. Recent studies also show that AKG has alleviative effect on oxidative stress as a source of energy and an antioxidant in mammalian cells. In this review, we highlight recent advances in the antioxidative function of AKG and its applications in animals and humans.

References

Feb 19, 2002·The Journal of Pharmacy and Pharmacology·Kazumi SanoTakashi Uesugi
Mar 1, 2002·Toxicology Letters·R BhattacharyaR Vijayaraghavan
Jan 12, 2005·Experimental Eye Research·S D Varma, K R Hegde
Sep 14, 2006·Fundamental & Clinical Pharmacology·K B DakshayaniM Mohamed Essa
Nov 26, 2008·Amino Acids·Guoyao WuYulong Yin
Jun 23, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R BhattacharyaP B Saxena
Aug 19, 2010·Oxidative Medicine and Cellular Longevity·Eric E Essick, Flora Sam
Aug 24, 2010·Trends in Biochemical Sciences·Ruth Scherz-Shouval, Zvulun Elazar
Sep 16, 2010·Free Radical Biology & Medicine·Simone ReuterBharat B Aggarwal
Jan 5, 2011·Frontiers in Bioscience (Landmark Edition)·Yongqing HouGuoyao Wu
Aug 7, 2012·Journal of Bone and Mineral Metabolism·Radoslaw Piotr RadzkiStefan Grzegorz Pierzynowski
Sep 8, 2012·Current Atherosclerosis Reports·Kai Chen, John F Keaney
Apr 24, 2013·Asian Pacific Journal of Tropical Medicine·Zhen-Guo ChengBao-Shun Du
May 8, 2014·Oxidative Medicine and Cellular Longevity·Mohammad AbdollahiSara Mostafalou
Jun 23, 2015·Journal of Gastroenterology and Hepatology·Raghupathy VenojiAnup Ramachandran
Sep 14, 2015·Environmental Toxicology and Pharmacology·Maria M BayliakVolodymyr I Lushchak
Feb 14, 2016·Brain Research·Tamil Selvan AnthonymuthuHülya Bayır
Nov 15, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Maria M BayliakVolodymyr I Lushchak
Jan 31, 2017·Journal of Medicinal Chemistry·Allimuthu T Dharmaraja
Feb 6, 2017·International Journal of Microbiology·Maria BayliakVolodymyr Lushchak
Feb 10, 2017·Postȩpy higieny i medycyny doświadczalnej·Dorota BrykDanuta Zapolska-Downar
Jun 9, 2017·Animal Science Journal = Nihon Chikusan Gakkaihō·Shuangshuang GuoBinying Ding
Oct 29, 2017·Redox Biology·C CheignonF Collin

❮ Previous
Next ❯

Citations

Aug 15, 2019·Clinical and Translational Science·Victoria MenziesDebra E Lyon
Oct 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Brandon J SonnAndrew A Monte
Jul 28, 2020·Genes·Elizabeth CabreraVerónica A Segarra
Jul 21, 2020·World Journal of Microbiology & Biotechnology·F LegendreV D Appanna
Jul 26, 2019·Molecular and Cellular Biochemistry·Miriam RussAstrid Ortner
Jan 5, 2021·Journal of Nutritional Science and Vitaminology·Churan FuNorihisa Kato
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yantong LiDonghai Lin
May 28, 2021·Frontiers in Microbiology·Kelly CraigAmy Grunden

❮ Previous
Next ❯

Methods Mentioned

BETA
MDA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.