The antiphospholipid (Hughes') syndrome: changing the face of neurology

European Journal of Internal Medicine
Christos E. Lampropoulos, G R V Hughes

Abstract

Hughes' syndrome (the antiphospholipid syndrome (APS)) presents with recurrent thrombosis, recurrent miscarriage and neurological disease. The major pathogenic mechanism of the syndrome is vascular obstruction (both venous and arterial) due to hypercoagulability. Neurological manifestations are prominent and are often the dominant feature. Headache, migraine and cognitive dysfunction are common while other manifestations such as dementia, epilepsy, chorea, multiple sclerosis (MS), psychiatric disease, transverse myelitis, ocular syndromes, sensorineural hearing loss and movement disorders are also associated with the syndrome. Anticoagulation therapy (either aspirin or oral anticoagulants) can lead to significant improvement.

References

Feb 1, 1989·Stroke; a Journal of Cerebral Circulation·M Kushner, N Simonian
Oct 15, 1983·British Medical Journal·G R Hughes
Apr 13, 1995·The New England Journal of Medicine·M A KhamashtaG R Hughes
Oct 1, 1996·Stroke; a Journal of Cerebral Circulation·M A DeschiensM G Bousser
Dec 1, 1996·AJR. American Journal of Roentgenology·J M ProvenzaleT L Ortel
Aug 1, 1997·The Journal of Clinical Investigation·L ZiporenA D Korczyn
Mar 10, 1998·The Journal of Clinical Psychiatry·M SchwartzD Attias
Jan 12, 2000·Dementia and Geriatric Cognitive Disorders·A MosekJ Chapman
Jan 4, 2001·The American Journal of Medicine·J T PeltolaT Keränen
Mar 15, 2001·Parkinsonism & Related Disorders·I Milanov, D Bogdanova
Jul 4, 2001·Lupus·M J CuadradoG R Hughes

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Citations

Aug 30, 2005·Annals of the New York Academy of Sciences·Giovanni SannaGraham R V Hughes
Apr 21, 2007·Pediatrics International : Official Journal of the Japan Pediatric Society·Tomoko UsugiMakiko Osawa
Jan 18, 2006·Clinical Neurology and Neurosurgery·Wolfgang MiesbachInge Scharrer
Apr 10, 2015·Current Rheumatology Reports·Cassyanne L AguiarBarry L Myones
Jul 4, 2016·Journal of Neurology·Chris J D HardyJason D Warren
Jan 17, 2012·The Journal of Rheumatology·Eleftheria P GrikaPanayiotis G Vlachoyiannopoulos
Mar 21, 2006·The Neurologist·Basil Ridha, Keith A Josephs

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