PMID: 16506359Mar 2, 2006Paper

The antiphospholipid syndrome: an update

Clinical Laboratory
Massimo Franchini

Abstract

Antiphospholipid syndrome is an autoimmune disorder defined by the association between antiphospholipid antibodies (i.e., lupus anticoagulant and anticardiolipin antibodies) and venous or arterial thrombosis or obstetric complications. In spite of the recent advances, many aspects of this disease remain unclear. Although the antigenic targets of this heterogeneous group of autoantibodies have been determined, being negatively charged phospholipids-binding proteins, their precise pathogenic mechanism is still being determined. The most important advances in the pathophysiology, diagnosis and treatment of this condition are discussed in this review.

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Revista de medicina de la Universidad de Navarra
J R YusteJ Prieto
Immunität und Infektion
M Steffen
Best Practice & Research. Clinical Rheumatology
Jean-Louis PasqualiThierry Martin
© 2021 Meta ULC. All rights reserved