The antiplasmodial and radical scavenging activities of flavonoids of Erythrina burttii

Acta Tropica
Abiy YenesewNorman C Waters

Abstract

The acetone extract of the root bark of Erythrina burttii showed in vitro antiplasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC(50) values of 0.97 ± 0.2 and 1.73 ± 0.5 μg/ml respectively. The extract also had radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical with an EC(50) value of 12.0 μg/ml. The isoflav-3-enes burttinol-A and burttinol-C, and the 2-arylbenzofuran derivative burttinol-D were identified as the most active antiplasmodial (IC(50)<10 μM) and free radical scavenging (EC(50)ca. 10 μM) principles. The acetone extract of E. burttii at 800 mg/kg/day, in a 4-day Plasmodium berghei ANKA suppressive test, showed in vivo antimalarial activity with 52% chemosuppression. In the same in vivo test, marginal activities were also observed for the extracts of the root and stem bark of Erythrina abyssinica and the root bark of Erythrina sacleuxii.

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Citations

Jan 2, 2016·Journal of Ethnopharmacology·Leonidah K OmosaThomas Efferth
Sep 12, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Liara MerlugoAndreas S L Mendez
Dec 24, 2014·Journal of Ethnopharmacology·Jane NamukobeVincent Dumontet
Aug 24, 2019·Phytotherapy Research : PTR·Pone Kamdem Boniface, Elizabeth Igne Ferreira
Jan 2, 2021·International Journal of Molecular Sciences·Tania Jiménez-CabreraMinarda De la O-Arciniega
Mar 26, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Samuel Baker ObakiroLydia Bunalema

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