The antiprogestins RU486 and ZK98299 affect follicle-stimulating hormone secretion differentially on estrus, but not on proestrus

Endocrinology
S J RingstromN B Schwartz

Abstract

Previous in vivo studies from our laboratory indicated that administration of the antiprogestin RU486 on proestrus suppresses both the preovulatory gonadotropin surges and the secondary FSH surge, suggesting a role for the progesterone receptor (PR) in the generation of these surges. The present study was designed to test the effects of another antiprogestin, ZK98299, which has been reported to block the PR through a mechanism different from that of RU486, on gonadotropin secretion in vivo. RU486 and ZK98299 (2 and 6 mg/kg) were administered s.c. at 1230 h on proestrus; uterine intraluminal fluid content, serum gonadotropins, and gonadotropin subunit messenger RNAs (mRNAs) were determined at 1830 h on proestrus and at 0900 h on estrus. At 1830 h on proestrus, both RU486 and ZK98299 at both doses caused equal suppression of the preovulatory FSH surge and FSHbeta mRNA. Both antiprogestins also equally attenuated the preovulatory LH surge at this time, with the higher doses causing greater suppression. In contrast, at 0900 h on estrus, the antiprogestins affected serum FSH differentially; only RU486 suppressed the secondary FSH surge despite the fact that both drugs prevented the release of uterine intraluminal fluid, confirming b...Continue Reading

References

Jun 1, 1991·The Journal of Endocrinology·J T Uilenbroek
Nov 1, 1986·Journal of Steroid Biochemistry·W ElgerR Rohde
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·M TrussM Beato
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C A BeckD P Edwards
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K DelabreE Milgrom
Nov 1, 1991·Trends in Endocrinology and Metabolism : TEM·E E Baulieu

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Citations

Mar 28, 2017·Molecular and Cellular Endocrinology·Djurdjica Coss
Feb 14, 2018·Journal of Molecular Endocrinology·Nandana Das, T Rajendra Kumar
Aug 31, 2000·Endocrinology·J L Turgeon, D W Waring
May 23, 2018·Endocrinology·Teresa K Woodruff

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