PMID: 2104916Jan 1, 1990Paper

The antipsoriatic compound anthralin influences bioenergetic parameters and redox properties of energy transducing membranes

The Journal of Investigative Dermatology
J FuchsL Packer

Abstract

Bioenergetic parameters and redox properties of energy transducing membranes in rat liver mitochondria and cyanobacteria were investigated in the presence of the antipsoriatic compound anthralin (1,8-dihydroxy-9-anthrone). Transmembrane pH and electrical gradients were determined using electron paramagnetic resonance spectroscopy. In mitochondria, ubiquinones 9,10 and other redox components of the electron transport chain are reduced by anthralin; the proton motive force is increased. In the absence of ADP, anthralin slightly stimulates mitochondrial cyanide-insensitive oxygen consumption. It is suggested that increased cyanide-insensitive respiration is due to enhanced autoxidation of mitochondrial components and/or catalyzed oxidation of anthralin. In the presence of ADP mitochondrial respiration is decreased, and ATP synthesis is inhibited. Uncoupler-induced mitochondrial respiration is also decreased by anthralin, indicating inhibition of the electron transport chain. In the cyanobacterium Synechococcus PCC 6311 anthralin increases the pH gradient and decreases ATP levels. Thus, anthralin acts as an electron donor to membrane associated redox components and inhibits ATP synthesis in two different biologic systems. In human ...Continue Reading

References

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Citations

Dec 18, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·P C M van de KerkhofK Papp
Apr 2, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alison McGillNick J Reynolds
Mar 1, 1995·Clinics in Dermatology·F Van RuissenJ Schalkwijk
Oct 1, 1993·Free Radical Biology & Medicine·J FuchsL Packer
May 1, 1992·The Journal of Investigative Dermatology·A B GottliebJ G Krueger
May 1, 1992·Archives of Biochemistry and Biophysics·W H Nitschmann, L Packer

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