The antipsychotic aripiprazole induces antinociceptive effects: Possible role of peripheral dopamine D2 and serotonin 5-HT1A receptors

European Journal of Pharmacology
Ana F Almeida-SantosFabrício A Moreira

Abstract

Aripiprazole is an antipsychotic that acts by multiple mechanisms, including partial agonism at dopamine D2 and serotonin 5-HT1A receptors. Since these neurotransmitters also modulate pain and analgesia, we tested the hypothesis that systemic or local administration of aripiprazole induces antinociceptive responses. Systemic aripiprazole (0.1-10 mg/kg; i.p.) injection in mice inhibited formalin-induced paw licking and PGE2-induced hyperalgesia in the paw pressure test. This effect was mimicked by intra-plantar administration (12.5-100 µg/paw) in the ipsi, but not contralateral, paw. The peripheral action of aripiprazole (100 µg/paw) was reversed by haloperidol (0.1-10 µg/paw), suggesting the activation of dopamine receptors as a possible mechanism. Accordingly, quinpirole (25-100 µg/paw), a full agonist at D2/D3 receptors, also reduced nociceptive responses.. In line with the partial agoniztic activity of aripiprazole, low dose of this compound inhibited the effect of quinpirole (both at 25 µg/paw). Finally, peripheral administration of NAN-190 (0.1-10 μg/paw), a 5-HT1A antagonist, also prevented aripiprazole-induced antinociception. In conclusion, systemic or local administration of aripiprazole induces antinociceptive effects...Continue Reading

References

Jan 1, 1992·Neuroscience·Y O Taiwo, J D Levine
Oct 1, 1991·Pharmacology, Biochemistry, and Behavior·M J Morgan, K B Franklin
Jun 1, 1985·Journal of Neuroscience Methods·S HunskaarK Hole
Feb 13, 1999·Progress in Neurobiology·M J Millan
May 14, 1999·General Pharmacology·M R ZarrindastM Pazouki
May 30, 2002·Progress in Neurobiology·Mark J Millan
Jun 14, 2002·European Journal of Pharmacology·Shaun JordanC Anthony Altar
Jun 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Kevin D BurrisPerry B Molinoff
Jun 5, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David A ShapiroRichard Mailman
Aug 29, 2003·The American Journal of Psychiatry·Paul E KeckUNKNOWN Aripiprazole Study Group
Oct 15, 2003·Archives of General Psychiatry·Gerhard GrunderDean F Wong
Dec 6, 2003·Pharmacological Reviews·Richard R NeubigUNKNOWN International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification
Jun 29, 2004·Clinical Therapeutics·Anthony DeLeonM Lynn Crismon
Jul 28, 2004·Trends in Pharmacological Sciences·Shitij Kapur
Aug 3, 2004·Nature Reviews. Drug Discovery·Ted T Ashburn, Karl B Thor
Jun 22, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·David M GardnerPaul Waraich
Jun 29, 2005·Journal of Psychopharmacology·R I Ohlsen, L S Pilowsky
Jun 30, 2006·Biological Psychiatry·Matthew W FeltensteinRonald E See
Mar 1, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sunmee WeeGeorge F Koob
Mar 21, 2007·Trends in Neurosciences·Susan D Iversen, Leslie L Iversen
May 7, 2008·Expert Review of Neurotherapeutics·Patrick B Wood
May 16, 2008·Psychopharmacology·Gunnar SørensenDavid P D Woldbye
Nov 18, 2008·Journal of Psychopharmacology·K J AitchisonG M Goodwin
Jan 29, 2009·Synapse·Stéphane PotvinSerge Marchand
Apr 4, 2009·Physiological Reviews·Jürgen Sandkühler
Aug 31, 2011·Nitric Oxide : Biology and Chemistry·Thiago R L RomeroIgor D G Duarte
Dec 3, 2011·European Journal of Pharmacology·Daniela da Fonseca PachecoIgor Dimitri Gama Duarte
Nov 20, 2012·Basic & Clinical Pharmacology & Toxicology·Thercia G VianaFabricio A Moreira
Aug 29, 2013·Therapeutic Advances in Psychopharmacology·Leonardo FeiRocco Domenico Mediati
Dec 12, 2013·CNS Drugs·Leandro Francisco Silva Bastos, Márcio Matos Coelho
Sep 15, 2014·European Journal of Pharmacology·Ana F Almeida-SantosFabricio A Moreira
Mar 1, 2015·European Journal of Pharmacology·Fabricio A Moreira, Jeffrey W Dalley

❮ Previous
Next ❯

Citations

Oct 16, 2016·The Journal of Pain : Official Journal of the American Pain Society·Darakhshan Jabeen Haleem, Shazia Nawaz
Sep 11, 2018·Anesthesia and Analgesia·Renata C M FerreiraThiago R L Romero
Apr 23, 2020·International Journal of Molecular Sciences·Adam StasiulewiczAnd Joanna I Sulkowska
Sep 29, 2020·Internal Medicine Journal·Michael M C WongK Y Mak
Aug 2, 2017·BioMed Research International·Renata Cristina Mendes FerreiraThiago Roberto Lima Romero
Apr 24, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Cheolmin ShinChangsu Han

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here