The antipyretic effect of flurbiprofen

European Journal of Pharmacology
A S van Miert, C T van Duin

Abstract

Flurbiprofen, like its predecessor ibuprofen, possesses antipyretic properties in the endotoxin-fevered rabbit. Comparison of flurbiprofen and ibuprofen at varying dosages, reveals that flurbiprofen is at least 15 times more potent in this species. In goats, flurbiprofen is more potent than in rabbits. Flurbiprofen inhibited the pyrogenic effect of intravenously administered leucocytic pyrogen, but it did not alter the release of leucocytic pyrogen from peritoneal exudate cells in vitro. Moreover, flurbiprofen did not inhibit endotoxin-induced release of endogenous pyrogen in vivo. Incubation of leucocytic pyrogen with flurbiprofen did not alter its pyrogenic poteny. These results suggest that the antipyretic activity of flurbiprofen is due neither to interference with endogenous pyrogen synthesis and release, nor to inactivation of circulating endogenous pyrogen.

References

Apr 1, 1976·The Journal of Pharmacy and Pharmacology·A S Milton
Mar 1, 1975·The Journal of Pharmacy and Pharmacology·A Blackham, R T Owen
Dec 15, 1975·Klinische Wochenschrift·W K Philipp-Dormston, R Siegert
Jan 1, 1971·Journal of Comparative Pathology·A S van Miert, A Atmakusuma
Sep 1, 1973·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R F MillsJ S Nicholson
Mar 1, 1974·Die Naturwissenschaften·W K Philipp-Dormston, R Siegert
Apr 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·S L HooS C Wang

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Citations

Dec 1, 1979·Agents and Actions·F HertzJ M Lwoff
Jan 1, 1979·General Pharmacology·W G Clark
Jan 1, 1987·Veterinary Research Communications·A S Van Miert
Jan 1, 1979·Ophthalmology·I H Leopold, D Murray
Feb 1, 1990·Acta Tropica·D ZwartR F Kooy
Dec 2, 2014·Environmental Toxicology and Pharmacology·Na NingXue Gang Li
Dec 1, 1983·Journal of Veterinary Pharmacology and Therapeutics·A S Van MiertP Bresloff
Jan 1, 1985·Psychopharmacology·L D ChaitC E Johanson
Mar 1, 1984·The Journal of Pharmacy and Pharmacology·H NakamuraM Shimizu

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