The antithrombotic effect of borneol related to its anticoagulant property

The American Journal of Chinese Medicine
Yan-Hong LiNing-Sheng Wang

Abstract

Borneol is consumed excessively in China and Southeast Asian countries particularly in combined formula for preventing cardiovascular disease, but few studies were conducted on its effects on thrombosis. In this study, the antithrombotic and antiplatelet activities of borneol were investigated on thrombosis in vivo and on platelet aggregation ex-vivo. In addition, the coagulation parameters and influence on fibrinolytic activity were also assessed. The results showed that borneol had concentration dependent inhibitory effects on arterio-venous shunt and venous thrombosis but no effect on ADP and AA-induced platelet aggregation. Meanwhile, borneol prolonged the coagulation parameters for prothrombin time (PT) and thrombin time (TT), but did not show any fibrinolytic activity. It suggested that the antithrombotic activity of borneol and its action in combined formula for preventing cardiovascular diseases might be due to anticoagulant activity rather than antiplatelet activity.

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Citations

Jun 24, 2009·Free Radical Biology & Medicine·Yaoping TangNathan S Bryan
Sep 3, 2011·Basic & Clinical Pharmacology & Toxicology·José Couras Silva-FilhoAldeídia P Oliveira
Jun 16, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Cen ChenZhi-Ning Xia
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May 29, 2021·Chinese Journal of Integrative Medicine·Yu-Zhuo ZhangMin-Zhou Zhang
May 22, 2021·Frontiers in Pharmacology·Yong LiJian Wang

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